USS De Soto
USS De Soto is a name used more than once by the U.S. Navy:
- USS De Soto (1859) was a Navy steamer that served during the American Civil War and in the West Indies.
- USS De Soto (1860) was a riverboat that was renamed General Lyon on 24 October 1862.
- See also
- USS DeSoto County (LST-1171)