USP11
| Ubiquitin specific peptidase 11 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | USP11 ; UHX1 | ||||||||||||
| External IDs | OMIM: 300050 MGI: 2384312 HomoloGene: 31252 GeneCards: USP11 Gene | ||||||||||||
| EC number | 3.4.19.12 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8237 | 236733 | |||||||||||
| Ensembl | ENSG00000102226 | ENSMUSG00000031066 | |||||||||||
| UniProt | P51784 | Q99K46 | |||||||||||
| RefSeq (mRNA) | NM_004651 | NM_145628 | |||||||||||
| RefSeq (protein) | NP_004642 | NP_663603 | |||||||||||
| Location (UCSC) | Chr X: 47.23 – 47.25 Mb | Chr X: 20.7 – 20.72 Mb | |||||||||||
| PubMed search | |||||||||||||
Ubiquitin carboxyl-terminal hydrolase 11 is an enzyme that in humans is encoded by the USP11 gene.[1][2]
Function
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23[2]
Interactions
USP11 has been shown to interact with RANBP9.[3]
References
- ↑ Puente XS, Sánchez LM, Overall CM, López-Otín C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. Vancouver style error (help)
- ↑ 2.0 2.1 "Entrez Gene: USP11 ubiquitin specific peptidase 11".
- ↑ Ideguchi H, Ueda A, Tanaka M, Yang J, Tsuji T, Ohno S et al. (Oct 2002). "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM". Biochem. J. 367 (Pt 1): 87–95. doi:10.1042/BJ20011851. PMC 1222860. PMID 12084015.
Further reading
- D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
- Swanson DA, Freund CL, Ploder L, McInnes RR, Valle D (1996). "A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders". Hum. Mol. Genet. 5 (4): 533–8. doi:10.1093/hmg/5.4.533. PMID 8845848.
- Brandau O, Nyakatura G, Jedele KB, Platzer M, Achatz H, Ross M et al. (1999). "UHX1 and PCTK1: precise characterisation and localisation within a gene-rich region in Xp11.23 and evaluation as candidate genes for retinal diseases mapped to Xp21.1-p11.2". Eur. J. Hum. Genet. 6 (5): 459–66. doi:10.1038/sj.ejhg.5200207. PMID 9801870.
- Stoddart KL, Jermak C, Nagaraja R, Schlessinger D, Bech-Hansen NT (1999). "Physical map covering a 2 Mb region in human xp11.3 distal to DX6849". Gene 227 (1): 111–6. doi:10.1016/S0378-1119(98)00564-2. PMID 9931462.
- Thiselton DL, McDowall J, Brandau O, Ramser J, d'Esposito F, Bhattacharya SS et al. (2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders". Genomics 79 (4): 560–72. doi:10.1006/geno.2002.6733. PMID 11944989.
- Ideguchi H, Ueda A, Tanaka M, Yang J, Tsuji T, Ohno S et al. (2003). "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM". Biochem. J. 367 (Pt 1): 87–95. doi:10.1042/BJ20011851. PMC 1222860. PMID 12084015.
- Angelats C, Wang XW, Jermiin LS, Copeland NG, Jenkins NA, Baker RT (2003). "Isolation and characterization of the mouse ubiquitin-specific protease Usp15". Mamm. Genome 14 (1): 31–46. doi:10.1007/s00335-002-3035-0. PMID 12532266.
- Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Schoenfeld AR, Apgar S, Dolios G, Wang R, Aaronson SA (2004). "BRCA2 Is Ubiquitinated In Vivo and Interacts with USP11, a Deubiquitinating Enzyme That Exhibits Prosurvival Function in the Cellular Response to DNA Damage". Mol. Cell. Biol. 24 (17): 7444–55. doi:10.1128/MCB.24.17.7444-7455.2004. PMC 506974. PMID 15314155.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.