UNC84A

Sad1 and UNC84 domain containing 1

Identifiers

SUN1 ; UNC84A

External IDs

OMIM: 607723 MGI: 1924303 HomoloGene: 11544 GeneCards: SUN1 Gene

Gene ontology
Molecular function	• protein binding • lamin binding
Cellular component	• acrosomal membrane • nuclear envelope • integral component of nuclear inner membrane • SUN-KASH complex
Biological process	• nuclear envelope organization • cytoskeletal anchoring at nuclear membrane • nuclear matrix anchoring at nuclear membrane
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000164828

ENSMUSG00000036817

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
0.86 – 0.94 Mb

Chr 5:
139.2 – 139.25 Mb

PubMed search

Protein unc-84 homolog A is a protein that in humans is encoded by the UNC84A gene.^[1]^[2]

This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.^[2]

References

↑ Dreger M, Bengtsson L, Schoneberg T, Otto H, Hucho F (Oct 2001). "Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane". Proc Natl Acad Sci U S A 98 (21): 11943–8. doi:10.1073/pnas.211201898. PMC 59747. PMID 11593002.
↑ 2.0 2.1 "Entrez Gene: UNC84A unc-84 homolog A (C. elegans)".

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nagase T, Ishikawa K, Suyama M et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Malone CJ, Fixsen WD, Horvitz HR, Han M (1999). "UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development". Development 126 (14): 3171–81. PMID 10375507.
Bray JD, Chennathukuzhi VM, Hecht NB (2002). "Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X". Genomics 79 (6): 799–808. doi:10.1006/geno.2002.6779. PMID 12036294.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Schirmer EC, Florens L, Guan T et al. (2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics". Science 301 (5638): 1380–2. doi:10.1126/science.1088176. PMID 12958361.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Padmakumar VC, Libotte T, Lu W et al. (2005). "The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope". J. Cell. Sci. 118 (Pt 15): 3419–30. doi:10.1242/jcs.02471. PMID 16079285.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Hasan S, Güttinger S, Mühlhäusser P et al. (2006). "Nuclear envelope localization of human UNC84A does not require nuclear lamins". FEBS Lett. 580 (5): 1263–8. doi:10.1016/j.febslet.2006.01.039. PMID 16445915.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Wang Q, Du X, Cai Z, Greene MI (2006). "Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome". DNA Cell Biol. 25 (10): 554–62. doi:10.1089/dna.2006.25.554. PMID 17132086.
Chi YH, Haller K, Peloponese JM, Jeang KT (2007). "Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes". J. Biol. Chem. 282 (37): 27447–58. doi:10.1074/jbc.M703098200. PMID 17631499.