UNC5C

Unc-5 homolog C (C. elegans)

Identifiers

UNC5C ; UNC5H3

External IDs

OMIM: 603610 MGI: 1095412 HomoloGene: 2765 GeneCards: UNC5C Gene

Gene ontology
Molecular function	• netrin receptor activity
Cellular component	• plasma membrane • integral component of membrane
Biological process	• apoptotic process • axon guidance • brain development • regulation of cell migration • anterior/posterior axon guidance • netrin-activated signaling pathway • positive regulation of apoptotic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000182168

ENSMUSG00000059921

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
96.08 – 96.47 Mb

Chr 3:
141.47 – 141.83 Mb

PubMed search

Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene.^[1]^[2]^[3]

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.^[3]

References

↑ Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M (May 1997). "Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors". Nature 386 (6627): 833–8. doi:10.1038/386833a0. PMID 9126742.
↑ Ackerman SL, Knowles BB (Dec 1998). "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23". Genomics 52 (2): 205–8. doi:10.1006/geno.1998.5425. PMID 9782087.
↑ 3.0 3.1 "Entrez Gene: UNC5C unc-5 homolog C (C. elegans)".

Further reading

Kennedy TE (2001). "Cellular mechanisms of netrin function: long-range and short-range actions.". Biochem. Cell Biol. 78 (5): 569–75. doi:10.1139/bcb-78-5-569. PMID 11103947.
Livesey FJ (2001). "Netrins and netrin receptors.". Cell. Mol. Life Sci. 56 (1–2): 62–8. doi:10.1007/s000180050006. PMID 11213262.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Thiebault K, Mazelin L, Pays L et al. (2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4173–8. doi:10.1073/pnas.0738063100. PMC 153067. PMID 12655055.
Geisbrecht BV, Dowd KA, Barfield RW et al. (2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. PMID 12810718.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kruger RP, Lee J, Li W, Guan KL (2005). "Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation". J. Neurosci. 24 (48): 10826–34. doi:10.1523/JNEUROSCI.3715-04.2004. PMID 15574733.
Llambi F, Lourenço FC, Gozuacik D et al. (2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase". EMBO J. 24 (6): 1192–201. doi:10.1038/sj.emboj.7600584. PMC 556396. PMID 15729359.
Li W, Aurandt J, Jürgensen C et al. (2006). "FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5". J. Cell. Sci. 119 (Pt 1): 47–55. doi:10.1242/jcs.02697. PMC 2248276. PMID 16371650.
Bernet A, Mazelin L, Coissieux MM et al. (2008). "Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies". Gastroenterology 133 (6): 1840–8. doi:10.1053/j.gastro.2007.08.009. PMC 2211510. PMID 17967459.