UNC5A

Unc-5 homolog A (C. elegans)

Identifiers

UNC5A ; UNC5H1

External IDs

OMIM: 607869 MGI: 894682 HomoloGene: 41474 GeneCards: UNC5A Gene

Gene ontology
Molecular function	• netrin receptor activity
Cellular component	• plasma membrane • integral component of membrane
Biological process	• apoptotic process • signal transduction • axon guidance • anterior/posterior axon guidance • regulation of apoptotic process • positive regulation of apoptotic process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000113763

ENSMUSG00000025876

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
176.24 – 176.31 Mb

Chr 13:
54.95 – 55.01 Mb

PubMed search

Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.^[1]

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM]^[1]

Interactions

UNC5A has been shown to interact with MAGED1.^[2]

References

↑ 1.0 1.1 "Entrez Gene: UNC5A unc-5 homolog A (C. elegans)".
↑ Williams, Megan E; Strickland Phyllis; Watanabe Ken; Hinck Lindsay (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". J. Biol. Chem. (United States) 278 (19): 17483–90. doi:10.1074/jbc.M300415200. ISSN 0021-9258. PMID 12598531.

Further reading

Arakawa H (2005). "Netrin-1 and its receptors in tumorigenesis". Nat. Rev. Cancer 4 (12): 978–87. doi:10.1038/nrc1504. PMID 15573119.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Williams ME, Strickland P, Watanabe K, Hinck L (2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". J. Biol. Chem. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.
Tanikawa C, Matsuda K, Fukuda S et al. (2003). "p53RDL1 regulates p53-dependent apoptosis". Nat. Cell Biol. 5 (3): 216–23. doi:10.1038/ncb943. PMID 12598906.
Thiebault K, Mazelin L, Pays L et al. (2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4173–8. doi:10.1073/pnas.0738063100. PMC 153067. PMID 12655055.
Geisbrecht BV, Dowd KA, Barfield RW et al. (2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. PMID 12810718.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Llambi F, Lourenço FC, Gozuacik D et al. (2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase". EMBO J. 24 (6): 1192–201. doi:10.1038/sj.emboj.7600584. PMC 556396. PMID 15729359.