UACA

Uveal autoantigen with coiled-coil domains and ankyrin repeats

Identifiers

UACA ; NUCLING

External IDs

OMIM: 612516 MGI: 1919815 HomoloGene: 74297 GeneCards: UACA Gene

Gene ontology
Molecular function	• molecular_function • protein binding
Cellular component	• extracellular region • nucleus • nuclear envelope • cytoplasm • mitochondrion • cytoskeleton • membrane • apoptosome • perinuclear region of cytoplasm • extracellular vesicular exosome
Biological process	• biological_process • intrinsic apoptotic signaling pathway in response to DNA damage • intrinsic apoptotic signaling pathway in response to oxidative stress • response to UV • positive regulation of protein import into nucleus • negative regulation of NF-kappaB import into nucleus • positive regulation of apoptotic process • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of inflammatory response
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000137831

ENSMUSG00000034485

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 15:
70.95 – 71.06 Mb

Chr 9:
60.79 – 60.88 Mb

PubMed search

Uveal autoantigen with coiled-coil domains and ankyrin repeats is a protein that in humans is encoded by the UACA gene.^[1]^[2]^[3]

References

↑ Yamada K, Senju S, Nakatsura T, Murata Y, Ishihara M, Nakamura S, Ohno S, Negi A, Nishimura Y (Feb 2001). "Identification of a novel autoantigen UACA in patients with panuveitis". Biochem. Biophys. Res. Commun. 280 (4): 1169–76. doi:10.1006/bbrc.2001.4189. PMID 11162650.
↑ Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
↑ "Entrez Gene: UACA uveal autoantigen with coiled-coil domains and ankyrin repeats".

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T; Bauch A; Ruffner H et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Brandenberger R; Wei H; Zhang S et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Beausoleil SA; Jedrychowski M; Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ohkura T; Taniguchi S; Yamada K et al. (2004). "Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves' disease". Biochem. Biophys. Res. Commun. 321 (2): 432–40. doi:10.1016/j.bbrc.2004.06.162. PMID 15358194.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.