U5 spliceosomal RNA
| U5 spliceosomal RNA | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of U5 | |
| Identifiers | |
| Symbol | U5 |
| Rfam | RF00020 |
| Other data | |
| RNA type | Gene; snRNA; splicing |
| Domain(s) | Eukaryota |
| GO | 0000351 0000353 0005682 0046540 |
| SO | 0000395 |
U5 RNA is a non-coding RNA that is a component of both types of known spliceosome.[1] The precise function of this molecule is unknown, though it is known that the 5' loop is required for splice site selection and p220 binding, and that both the 3' stem-loop and the Sm site are important for Sm protein binding and cap methylation.
References
- ↑ Hinz M, Moore MJ, Bindereif A (August 1996). "Domain analysis of human U5 RNA. Cap trimethylation, protein binding, and spliceosome assembly". J. Biol. Chem. 271 (31): 19001–19007. doi:10.1074/jbc.271.31.19001. PMID 8702566.
Further reading
- Zwieb, C (1997). "The uRNA database". Nucleic Acids Res 25 (1): 102–103. doi:10.1093/nar/25.1.102. PMC 146409. PMID 9016512.
- Thomas, J; Lea K; Zucker-Aprison E; Blumenthal T (1990). "The spliceosomal snRNAs of Caenorhabditis elegans". Nucleic Acids Res 18 (9): 2633–2642. doi:10.1093/nar/18.9.2633. PMC 330746. PMID 2339054.