U2 small nuclear RNA auxiliary factor 1

U2 small nuclear RNA auxiliary factor 1

PDB rendering based on 1jmt.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsU2AF1 ; FP793; RN; RNU2AF1; U2AF35; U2AFBP
External IDsOMIM: 191317 MGI: 98884 HomoloGene: 134334 GeneCards: U2AF1 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez7307108121
EnsemblENSG00000160201ENSMUSG00000061613
UniProtQ01081Q9D883
RefSeq (mRNA)NM_001025203NM_001163769
RefSeq (protein)NP_001020374NP_001157241
Location (UCSC)Chr 21:
44.51 – 44.53 Mb		Chr 17:
31.65 – 31.66 Mb
PubMed search

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.[1][2][3]

Function

This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

Interactions

U2 small nuclear RNA auxiliary factor 1 has been shown to interact with:

References

  1. ↑ Lalioti MD, Gos A, Green MR, Rossier C, Morris MA, Antonarakis SE (January 1997). "The gene for human U2 snRNP auxiliary factor small 35-kDa subunit (U2AF1) maps to the progressive myoclonus epilepsy (EPM1) critical region on chromosome 21q22.3". Genomics 33 (2): 298–300. doi:10.1006/geno.1996.0196. PMID 8660980.
  2. ↑ Kalcheva I, Plass C, Sait S, Eddy R, Shows T, Watkins-Chow D et al. (Dec 1994). "Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5". Cytogenet Cell Genet 68 (1–2): 19–24. doi:10.1159/000133881. PMID 7956352.
  3. ↑ 3.0 3.1 "Entrez Gene: U2AF1 U2 small nuclear RNA auxiliary factor 1".
  4. ↑ Xiao SH, Manley JL (November 1998). "Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2". EMBO J. 17 (21): 6359–67. doi:10.1093/emboj/17.21.6359. PMC 1170960. PMID 9799243.
  5. ↑ Zhang WJ, Wu JY (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. 16 (10): 5400–8. PMC 231539. PMID 8816452.
  6. ↑ Zolotukhin AS, Tan W, Bear J, Smulevitch S, Felber BK (February 2002). "U2AF participates in the binding of TAP (NXF1) to mRNA". J. Biol. Chem. 277 (6): 3935–42. doi:10.1074/jbc.M107598200. PMID 11724776.
  7. ↑ Maita H, Kitaura H, Keen TJ, Inglehearn CF, Ariga H, Iguchi-Ariga SM (November 2004). "PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor". Exp. Cell Res. 300 (2): 283–96. doi:10.1016/j.yexcr.2004.07.029. PMID 15474994.
  8. ↑ Little JT, Jurica MS (March 2008). "Splicing factor SPF30 bridges an interaction between the prespliceosome protein U2AF35 and tri-small nuclear ribonucleoprotein protein hPrp3". J. Biol. Chem. 283 (13): 8145–52. doi:10.1074/jbc.M707984200. PMID 18211889.
  9. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  10. ↑ Zhang M, Zamore PD, Carmo-Fonseca M, Lamond AI, Green MR (September 1992). "Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit". Proc. Natl. Acad. Sci. U.S.A. 89 (18): 8769–73. doi:10.1073/pnas.89.18.8769. PMC 50002. PMID 1388271.
  11. ↑ Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (July 2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987.

Further reading