Tylonycteris bat coronavirus HKU4

Bat-CoV HKU4
Virus classification
Group: Group IV ((+)ssRNA)
Order: Nidovirales
Family: Coronaviridae
Subfamily: Coronavirinae
Genus: Betacoronavirus
Species: Tylonycteris bat coronavirus HKU4

Tylonycteris bat coronavirus HKU4 (Bat-CoV HKU4) is an enveloped, positive sense, single-stranded RNA mammalian Group 2 betacoronavirus that has been found to be genetically related to the Middle East respiratory syndrome coronavirus (MERS-CoV) that is responsible for the 2012 Middle East respiratory syndrome coronavirus outbreaks in Saudi Arabia, Jordan, United Arab Emirates, the United Kingdom, France, and Italy.[1][2][3][4]

Transmission

The exact means of transmission to humans is not yet well known. However, it has been demonstrated that betaCoV's including HKU4 have the propensity to recombine and cause interspecies transmission. However, this is not seen in Group C betaCov's to which MERS-CoV is most closely related.[5]

See also

References

  1. ↑ Woo, Patrick CY; Lau, Susanna KP; Li, Kenneth SM; Tsang, Alan KL; Yuen, Kwok-Yung (2012). "Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5". Emerging Microbes & Infections 1 (11): e35–. doi:10.1038/emi.2012.45. PMC 3630921.
  2. ↑ Zaki, Ali M.; Van Boheemen, Sander; Bestebroer, Theo M.; Osterhaus, Albert D.M.E.; Fouchier, Ron A.M. (2012). "Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia". New England Journal of Medicine 367 (19): 1814–20. doi:10.1056/NEJMoa1211721. PMID 23075143.
  3. ↑ Woo, Patrick C.Y.; Lau, Susanna K.P.; Li, Kenneth S.M.; Poon, Rosana W.S.; Wong, Beatrice H.L.; Tsoi, Hoi-wah; Yip, Bethanie C.K.; Huang, Yi; Chan, Kwok-Hung; Yuen, Kwok-Yung (2006). "Molecular diversity of coronaviruses in bats". Virology 351 (1): 180–7. doi:10.1016/j.virol.2006.02.041. PMID 16647731.
  4. ↑ Lau, S. K. P.; Li, K. S. M.; Tsang, A. K. L.; Lam, C. S. F.; Ahmed, S.; Chen, H.; Chan, K.-H.; Woo, P. C. Y.; Yuen, K.-Y. (2013). "Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus". Journal of Virology 87 (15): 8638–50. doi:10.1128/JVI.01055-13. PMC 3719811. PMID 23720729.
  5. ↑ Woo, Patrick C. Y.; Huang, Yi; Lau, Susanna K. P.; Yuen, Kwok-Yung (2010). "Coronavirus Genomics and Bioinformatics Analysis". Viruses 2 (8): 1804–20. doi:10.3390/v2081803. PMC 3185738. PMID 21994708.

External links