Tribendimidine
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| Systematic (IUPAC) name | |
|---|---|
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N,N'-bis(4-(1-dimethylamino)ethylideneaminophenyl)-1,4 -phenylene dimethylidyneamine | |
| Clinical data | |
| Identifiers | |
115103-15-6  | |
| None | |
| PubChem | CID 3086564 |
| ChemSpider |
2343161  |
| ChEMBL |
CHEMBL427256 |
| Chemical data | |
| Formula | C28H32N6 |
| 452.594 g/mol | |
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SMILES
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Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.[1]
In clinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis.[2] However, animal studies suggest it is ineffective in treating Schistosoma mansoni or Fasciola hepatica disease.[1]
Tribendimidine is associated with Shandong Xinhua Pharmaceutical Company Limited in Zibo, Shandong, China.
References
- ↑ 1.0 1.1 Keiser J, Shu-Hua X, Chollet J, Tanner M, Utzinger J (2007). "Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini". Antimicrob Agents Chemother 51 (3): 1096–8. doi:10.1128/AAC.01366-06. PMC 1803157. PMID 17194822. Free full text.
- ↑ Xiao SH, Hui-Ming W, Tanner M, Utzinger J, Chong W (2005). "Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China". Acta Trop 94 (1): 1–14. doi:10.1016/j.actatropica.2005.01.013. PMID 15777691.
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