Tremorine

Tremorine
Systematic (IUPAC) name
1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidine
Clinical data
Identifiers
51-73-0
None
PubChem CID 5534
Chemical data
Formula C12H20N2
192.300

Tremorine is a drug which is used in scientific research to produce tremor in animals. This is used for the development of drugs for the treatment of Parkinson's disease, as tremor is a major symptom which is treated by anti-Parkinson's drugs.[1][2][3][4][5] Beta blockers are also effective in counteracting the effects of tremorine.[6]

References

  1. ↑ Trautner, E. M.; Gershon, S. (1959). "Use of 'Tremorine' for screening Anti-Parkinsonian Drugs". Nature 183 (4673): 1462–1463. doi:10.1038/1831462a0. PMID 13657170.
  2. ↑ Friedman, A. H.; Aylesworth, R. J.; Friedman, G. (1963). "Tremorine: Its Effect on Amines of the Central Nervous System". Science 141 (3586): 1188–1190. doi:10.1126/science.141.3586.1188. PMID 14043364.
  3. ↑ Menon, M.; Clark, W. G.; Aures, D. (1971). "Effect of tremorine, oxotremorine and decaborane on brain histamine levels in rats". Pharmacological Research Communications 3 (4): 345. doi:10.1016/0031-6989(71)90005-1.
  4. ↑ Shinozaki, H.; Hirate, K.; Ishida, M. (1985). "Further studies on quantification of drug-induced tremor in mice: Effects of antitremorgenic agents on tremor frequency". Experimental neurology 88 (2): 303–315. doi:10.1016/0014-4886(85)90193-1. PMID 3987859.
  5. ↑ Morais, L.; Quintansjunior, L.; Franco, C.; Almeida, J.; Almeida, R. (2004). "Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology". Pharmacology Biochemistry and Behavior 79 (4): 745–749. doi:10.1016/j.pbb.2004.10.004. PMID 15582683.
  6. ↑ Paul, V. (1986). "The role of adrenergic mechanism in tremorine-induced tremors in rats: Antitremor effect of beta-adrenoceptor antagonists". Indian journal of physiology and pharmacology 30 (4): 307–312. PMID 2883120.

See also