Transcription initiation protein SPT3 homolog

Suppressor of Ty 3 homolog (S. cerevisiae)

Identifiers

SUPT3H ; SPT3; SPT3L

External IDs

OMIM: 602947 MGI: 1923723 HomoloGene: 121570 GeneCards: SUPT3H Gene

Gene ontology
Molecular function	• transcription coactivator activity • histone acetyltransferase activity • protein heterodimerization activity
Cellular component	• nucleus • nucleolus • cytoplasm • STAGA complex • transcription factor TFTC complex
Biological process	• chromatin organization • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • histone deubiquitination • histone H3 acetylation • positive regulation of transcription, DNA-templated
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000196284

ENSMUSG00000038954

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
44.78 – 45.35 Mb

Chr 17:
44.78 – 45.12 Mb

PubMed search

Transcription initiation protein SPT3 homolog is a protein that in humans is encoded by the SUPT3H gene.^[1]^[2]^[3]

Interactions

Transcription initiation protein SPT3 homolog has been shown to interact with GCN5L2,^[4]^[5] TAF6L,^[5] TADA3L,^[5] TAF5L,^[5] SF3B3,^[5] SUPT7L,^[5] Myc,^[6] TAF9,^[5] Transformation/transcription domain-associated protein,^[5] TAF12,^[5] TAF10,^[4]^[5] TAF4^[4] and DDB1.^[5]

References

↑ Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (August 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell 94 (1): 35–44. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425.
↑ Martinez E, Kundu TK, Fu J, Roeder RG (October 1998). "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID". J Biol Chem 273 (37): 23781–5. doi:10.1074/jbc.273.37.23781. PMID 9726987.
↑ "Entrez Gene: SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)".
↑ 4.0 4.1 4.2 Brand, M; Moggs J G; Oulad-Abdelghani M; Lejeune F; Dilworth F J; Stevenin J; Almouzni G; Tora L (June 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". EMBO J. (England) 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. ISSN 0261-4189. PMC 150203. PMID 11406595.
↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 5.9 5.10 Martinez, E; Palhan V B; Tjernberg A; Lymar E S; Gamper A M; Kundu T K; Chait B T; Roeder R G (October 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Mol. Cell. Biol. (United States) 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. ISSN 0270-7306. PMC 99856. PMID 11564863.
↑ Liu, Xiaohui; Tesfai Jerusalem; Evrard Yvonne A; Dent Sharon Y R; Martinez Ernest (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". J. Biol. Chem. (United States) 278 (22): 20405–12. doi:10.1074/jbc.M211795200. ISSN 0021-9258. PMC 4031917. PMID 12660246.

Further reading

Yu J, Madison JM, Mundlos S et al. (1998). "Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor spt3 (SUPT3H).". Genomics 53 (1): 90–6. doi:10.1006/geno.1998.5500. PMID 9787080.
Vassilev A, Yamauchi J, Kotani T et al. (1999). "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily.". Mol. Cell 2 (6): 869–75. doi:10.1016/S1097-2765(00)80301-9. PMID 9885574.
Brand M, Yamamoto K, Staub A, Tora L (1999). "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.". J. Biol. Chem. 274 (26): 18285–9. doi:10.1074/jbc.274.26.18285. PMID 10373431.
Speek M (2001). "Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes.". Mol. Cell. Biol. 21 (6): 1973–85. doi:10.1128/MCB.21.6.1973-1985.2001. PMC 86790. PMID 11238933.
Brand M, Moggs JG, Oulad-Abdelghani M et al. (2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation.". EMBO J. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595.
Martinez E, Palhan VB, Tjernberg A et al. (2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cavusoglu N, Brand M, Tora L, Van Dorsselaer A (2003). "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis.". Proteomics 3 (2): 217–23. doi:10.1002/pmic.200390030. PMID 12601814.
Liu X, Tesfai J, Evrard YA et al. (2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation.". J. Biol. Chem. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246.