Tonofibril
Tonofibrils are cytoplasmic protein structures in epithelial tissues[1] that converge at desmosomes and hemidesmosomes.
Tonofilaments are also associated with desmosomes (macula adherens), anchoring them to the cytoskeleton.
Composition
They are made of keratin (a type of intermediate filament in the cytoskeleton) tonofilaments.[2] Tonofilaments are keratin intermediate filaments that make up tonofibrils in epithelial tissue. In epithelial cells, tonofilaments loop through desmosomes.
The protein filaggrin is believed to have an important role in holding them together as tonofibrils.
References
External links
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| | Human | |
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| | Nonhuman | |
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| See also: cytoskeletal defects Index of cells |
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| | Description |
- Structure
- Organelles
- peroxisome
- cytoskeleton
- centrosome
- epithelia
- cilia
- mitochondria
- Membranes
- Membrane transport
- ion channels
- vesicular transport
- solute carrier
- ABC transporters
- ATPase
- oxidoreduction-driven
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| | Disease |
- Structural
- peroxisome
- cytoskeleton
- cilia
- mitochondria
- nucleus
- scleroprotein
- Membrane
- channelopathy
- solute carrier
- ATPase
- ABC transporters
- other
- extracellular ligands
- cell surface receptors
- intracellular signalling
- Vesicular transport
- Pore-forming toxins
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| | Lateral/cell-cell | |
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| | Basal/cell-matrix | |
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| | Apical | |
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| Index of cells |
|---|
| | Description |
- Structure
- Organelles
- peroxisome
- cytoskeleton
- centrosome
- epithelia
- cilia
- mitochondria
- Membranes
- Membrane transport
- ion channels
- vesicular transport
- solute carrier
- ABC transporters
- ATPase
- oxidoreduction-driven
|
|---|
| | Disease |
- Structural
- peroxisome
- cytoskeleton
- cilia
- mitochondria
- nucleus
- scleroprotein
- Membrane
- channelopathy
- solute carrier
- ATPase
- ABC transporters
- other
- extracellular ligands
- cell surface receptors
- intracellular signalling
- Vesicular transport
- Pore-forming toxins
|
|---|
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