Tombusvirus internal replication element (IRE)

Tombusvirus internal replication element (IRE)
Predicted secondary structure and sequence conservation of Tombus_IRE
Identifiers
Symbol Tombus_IRE
Rfam RF00510
Other data
RNA type Cis-reg
Domain(s) Viruses
SO 0000233

In virology, the tombusvirus internal replication element (IRE) is a segment of RNA located within the region coding for p92 polymerase. This element is essential for viral replication; specifically, it is thought to be required at an early stage of replication, such as template recruitment and/or replicase complex assembly.[1]

Other non-coding RNA structures in Tombusvirus include the 3' UTR region IV[2] and 5' UTR.[3][4]

References

  1. ↑ Monkewich, S; Lin HX; Fabian MR; Xu W; Na H; Ray D; Chernysheva OA; Nagy PD; White KA (2005). "The p92 Polymerase Coding Region Contains an Internal RNA Element Required at an Early Step in Tombusvirus Genome Replication". J Virol 79 (8): 4848–4858. doi:10.1128/JVI.79.8.4848-4858.2005. PMC 1069561. PMID 15795270.
  2. ↑ Fabian MR, Na H, Ray D, White KA (2003). "3'-Terminal RNA secondary structures are important for accumulation of tomato bushy stunt virus DI RNAs". Virology 313 (2): 567–80. doi:10.1016/S0042-6822(03)00349-0. PMID 12954222.
  3. ↑ Wu B, Vanti WB, White KA (2001). "An RNA domain within the 5' untranslated region of the tomato bushy stunt virus genome modulates viral RNA replication". J. Mol. Biol. 305 (4): 741–56. doi:10.1006/jmbi.2000.4298. PMID 11162089.
  4. ↑ Ray D, Na H, White KA (2004). "Structural properties of a multifunctional T-shaped RNA domain that mediate efficient tomato bushy stunt virus RNA replication". J. Virol. 78 (19): 10490–500. doi:10.1128/JVI.78.19.10490-10500.2004. PMC 516415. PMID 15367615.

External links