Tocofersolan

Tocofersolan
Names
IUPAC name
α-[4-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-poly(oxy-1,2-ethanediyl)
Other names
Tocofersolan; Vitamin E PEG succinate; α-Tocopherol polyethylene glycol succinate; Liqui-E
Identifiers
ATC code A11HA08
9002-96-4
ChemSpider 64498 Yes
Jmol-3D images Image
PubChem 9938056
UNII O03S90U1F2 Yes
Properties
(C2H4O)nC33H54O5
Molar mass Variable
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Tocofersolan (INN) or tocophersolan is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is polyethylene glycol derivative of α-tocopherol that enables water solubility.

Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease.[1] On 24 July 2009 the European Medicines Agency approved tocofersolan under the trade name Vedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestive malabsorption in paediatric patients suffering from congenital or hereditary chronic cholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region).[2]

Tocofersolan is also used in cosmetics and pharmaceuticals as an antioxidant.[3]

References

  1. ↑ "Tocophersolan Oral". WebMD.
  2. ↑ "Vedrop Summary of Product Characteristics" (PDF). European Medicines Agency.
  3. ↑ Ash, Michael; Ash, Irene. Handbook of Preservatives. p. 568. ISBN 1-890595-66-7.