Tixocortol

Tixocortol
Systematic (IUPAC) name

(11β)-11,17-dihydroxy-21-mercaptopregn-4-ene-3,20-dione
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Identifiers
CAS Registry Number	61951-99-3^N
ATC code	A07EA05 R01AD07
PubChem	CID 162955
ChemSpider	143053^Y
UNII	ZX3KEK657Z^Y
KEGG	D08610^Y
Synonyms	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-mercaptoacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
Chemical data
Formula	C₂₁H₃₀O₄S
Molecular mass	378.527 g/mol
SMILES O=C4\C=C2/[C@]([C@H]1[C@@H](O)C[C@@]3([C@@](O)(C(=O)CS)CC[C@H]3[C@@H]1CC2)C)(C)CC4
InChI InChI=1S/C21H30O4S/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-26)20(15,2)10-16(23)18(14)19/h9,14-16,18,23,25-26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 ^Y Key:YWDBSCORAARPPF-VWUMJDOOSA-N ^Y
N (what is this?) (verify)

Tixocortol is a corticosteroid used as an intestinal anti-inflammatory^[1] and decongestant.

References

↑ Larochelle, P.; Du Souich, P.; Bolte, E.; Lelorier, J.; Goyer, R. (1983). "Tixocortol pivalate, a corticosteroid with no systemic glucocorticoid effect after oral, intrarectal, and intranasal application". Clinical pharmacology and therapeutics 33 (3): 343–350. doi:10.1038/clpt.1983.43. PMID 6402333.

Glucocorticoids and antiglucocorticoids (H02)

Agonists

Pregnene	Cortisone

Pregnenedione	Hydrocortisone (cortisol)^# (Hydrocortisone aceponate Hydrocortisone buteprate Hydrocortisone butyrate) Budesonide Ciclesonide Deflazacort Medrysone Tixocortol HALOGENATED AT 6: Cloprednol HALOGENATED, WITH FG AT 16: Halcinonide

Pregnadiene	Rimexolone HALOGENATED, WITH FG AT 16: Flunisolide Triamcinolone Amcinonide Fluocinolone acetonide (Fluocinonide)

Pregnadienediol	Prednisone (Meprednisone) HALOGENATED AT 9: Fluorometholone HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone Diflucortolone Fluocortin) Desoximetasone

Pregnadienetriol	Prednisolone^# (Methylprednisolone Methylprednisolone aceponate Prednicarbate Prednylidene) Desonide HALOGENATED: Fluprednisolone (Difluprednate Fluperolone) HALOGENATED, WITH FG AT 16: Dexamethasone^# Betamethasone (Clobetasol Clobetasone Diflorasone Halometasone Ulobetasol) Beclometasone Paramethasone Alclometasone Fluclorolone acetonide Flumetasone Fluprednidene

Pregnatriene	Cortivazol

Androstene	HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate Fluticasone furoate)

Others/unsorted	HALOGENATED: Loteprednol HALOGENATED, WITH FG AT 16: Fludroxycortide Formocortal Mometasone furoate

Antagonists /
SGRMs

SGRMs: Mapracorat

Antagonists: Mifepristone

Synthesis modifiers

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Index of hormones

Description	Glands Hormones thyroid intermediates metabolism mineralocorticoids Physiology Development

Disease	Diabetes Congenital Neoplasms and cancer Other Symptoms and signs eponymous

Treatment	Procedures Drugs calcium balance corticosteroids oral hypoglycemics pituitary and hypothalamic thyroid

Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07)

Rehydration

Oral rehydration therapy

Intestinal anti-infectives

Antibiotics
- Amphotericin B
- Colistin
- Fidaxomicin
- Kanamycin
- Natamycin
- Neomycin
- Nystatin
- Paromomycin
- Polymyxin B
- Rifaximin
- Streptomycin
- Vancomycin

Sulfonamides

Nitrofuran
- Nifuroxazide
- Nifurzide)

Imidazole
- Miconazole

Arsenical
- Acetarsol

Oxyquinoline
- Broxyquinoline

Intestinal adsorbents

Antipropulsives (opioids)

crosses BBB: Diphenoxylate (Diphenoxylate/atropine)
Difenoxin

does not cross BBB: Loperamide

Intestinal anti-inflammatory agents

corticosteroids acting locally

antiallergic agents, excluding corticosteroids
- Cromoglicic acid

aminosalicylic acid and similar agents

Antidiarrheal micro-organisms

Saccharomyces boulardii

Other antidiarrheals

Index of digestion

Description	Anatomy tract glands other Physiology enzymes Development

Disease	Congenital Neoplasms and cancer Inflammatory bowel disease Gluten sensitivity Other Symptoms and signs eponymous Blood tests

Treatment	Procedures Drugs anabolic steroids antacids diarrhoea and infection bile and liver functional gastrointestinal disorders laxatives peptic ulcer and reflux nausea and vomiting other Surgery

Decongestants and other nasal preparations (R01)

Topical

Sympathomimetics, plain	Cyclopentamine Ephedrine Phenylephrine Oxymetazoline Tetryzoline Xylometazoline Naphazoline Tramazoline Metizoline Tuaminoheptane Fenoxazoline Tymazoline Epinephrine

Antiallergic agents, excluding corticosteroids	Spaglumic acid histamine antagonists (Levocabastine Antazoline Thonzylamine) mast cell stabilizer (some are also antihistamines) (Cromoglicic acid Nedocromil Azelastine Olopatadine Lodoxamide)

Corticosteroids	Beclometasone Prednisolone Dexamethasone Flunisolide Budesonide Betamethasone Tixocortol Fluticasone Mometasone furoate Triamcinolone Ciclesonide

Other nasal preparations	Cafaminol Calcium hexamine thiocyanate Retinol Ipratropium bromide Ritiometan Mupirocin Hexamidine Framycetin Hyaluronic acid Eucalyptus oil Saline

Systemic use:
Sympathomimetics

Index of the respiratory system

Description	Anatomy nose larynx lower thorax Physiology Development

Disease	Congenital Neoplasms and cancer Chest trauma Infection common cold pneumonia tuberculosis Other Symptoms and signs eponymous

Treatment	Procedures mechanical ventilation Drugs nasal throat obstructive airway diseases cough and cold histaminergics pulmonary arterial hypertension other Surgery

Glucocorticoidics

Receptor

Agonists: 11-Deoxycorticosterone
11-Deoxycortisol (cortodoxone)
Acrocinonide
Alclometasone
Amcinafal
Amcinafide
Amcinonide
Amebucort
Amelometasone
Amicinonide
Anecortave
Beclometasone
Beclometasone dipropionate
Betamethasone
Betamethasone acibutate
Betamethasone dipropionate
Budesonide
Butixocort
Chloroprednisone
Ciclesonide
Cicortonide
Ciprocinonide
Clobetasol
Clobetasol propionate
Clobetasone
Clocortolone
Cloprednol
Cloticasone
Cormetasone
Corticosterone
Cortisone
Cortisuzol
Cortivazol
Deflazacort
Deprodone
Descinolone
Desonide
Desoximetasone
Desoxycortone
Dexbudesonide
Dexamethasone
Dexamethasone acefurate
Dexamethasone cipecilate
Dexamethasone isonicotinate
Dichlorisone
Diflorasone
Difluocortolone
Difluocortolone valerate
Difluprednate
Domoprednate
Doxibetasol
Drocinonide
Etiprednol dicloacetate
Fluazacort
Fluclorolone
Fluclorolone (flucloronide)
Fludrocortisone
Fludroxycortide
Flumoxonide
Flumetasone
Flunisolide
Fluocinolone
Fluocinolone acetonide
Fluocinonide
Fluocortin
Fluocortolone
Fluorometholone
Fluperolone
Fluperolone acetate
Fluprednidene
Fluprednidene acetate
Fluprednisolone
Fluticasone
Fluticasone furoate
Fluticasone propionate
Formocortal
GSK-9027
Halcinonide
Halocortolone
Halometasone
Halopredone
Hydrocortamate
Hydrocortisone (cortisol)
Hydrocortisone aceponate
Hydrocortisone buteprate
Hydrocortisone-17-butyrate
Hydrocortisone-21-butyrate
Icometasone enbutate
Isoflupredone
Isoprednidene
Itrocinonide
Locicortolone dicibate
Loteprednol
Mazipredone
Meclorisone
Medrysone
Meprednisone
Methylprednisolone
Methylprednisolone aceponate
Methylprednisolone suleptanate
Mometasone
Mometasone furoate
Naflocort
Nicocortonide
Nivacortol
Oxisopred
Paramethasone
Prednazate
Prednazoline
Prednicarbate
Prednimustine
Prednisolamate
Prednisolone
Prednisolone steaglate
Prednisone
Prednylidene
Procinonide
Resocortol
Rimexolone
Rofleponide
Timobesone
Tipredane
Tixocortol
Tixocortol pivalate
Tralonide
Triamcinolone
Triamcinolone acetonide
Triamcinolone benetonide
Triamcinolone furetonide
Triamcinolone hexacetonide
Triclonide
Ulobetasol (halobetasol)

Mixed (SEGRAs): Mapracorat
PF-04171327

Antagonists: Aglepristone
Asoprisnil
C108297
C113176
CORT-108297
Cyproterone acetate
Ketoconazole
Lilopristone
LLY-2707
Mifepristone
Onapristone
Org 34850
PCN
Telapristone
Toripristone
Ulipristal acetate

Enzyme

See here instead (modulators of 20,22-desmolase, 17α-hydroxylase/17,20-lyase, 3β-HSD, 11β-HSD, 21-hydroxylase, 11β-hydroxylase, and 18-hydroxylase).

Others

See also: Androgenics • Estrogenics • Mineralocorticoidics • Progestogenics