Thiorphan

Thiorphan
Systematic (IUPAC) name
(±)-2-[(2-benzyl-3-sulfanyl-propanoyl)amino]acetic acid
Clinical data
Identifiers
76721-89-6 
PubChem CID 3132
DrugBank DB08626 
ChemSpider 3020 Yes
UNII B79L7B5X3Z Yes
ChEMBL CHEMBL10247 Yes
Chemical data
Formula C12H15NO3S
253.32 g/mol
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Thiorphan is the active metabolite of the antidiarrheal racecadotril (acetorphan).[1] It prevents the degradation of endogenous enkephalins by acting as an enkephalinase inhibitor.[1]

See also

References

  1. ↑ 1.0 1.1 Spillantini MG, Geppetti P, Fanciullacci M, Michelacci S, Lecomte JM, Sicuteri F (June 1986). "In vivo 'enkephalinase' inhibition by acetorphan in human plasma and CSF". European Journal of Pharmacology 125 (1): 147–50. doi:10.1016/0014-2999(86)90094-4. PMID 3015640.