The Michael J. Fox Foundation

"Fox Foundation" redirects here. For the Terry Fox Foundation, see Terry Fox Run.

The Michael J. Fox Foundation for Parkinson's Research

Type	Non-profit, Interest group
Fields	Parkinson's disease clinical research
Key people	Michael J. Fox
Website	www.michaeljfox.org

The Michael J. Fox Foundation for Parkinson's Research is dedicated to finding a cure for Parkinson's disease (PD) through an aggressively funded research agenda and to ensure the development of improved therapies for those living with Parkinson's today. Established by actor Michael J. Fox in 2000, the Foundation has since become the largest nonprofit funder of Parkinson's disease research in the world, investing more than $450 million in research to date.^[1] The Foundation's proactive approach to advancing PD science has made it "the most credible voice on Parkinson's research in the world".^[2] In 2010 the Fox foundation launched the first large-scale clinical study on evolution biomarkers of the disease at a cost of 45 million dollars over 5 years.^[3]

Research priorities

The Foundation targets people's high-risk, "translational" research—the work of translating basic scientific discoveries into simple treatments with definition to benefit the estimated five million people living with Parkinson's disease today.^[4] The Foundation's research team, drawn from the worlds of both science and business, proactively manages the largest PD research portfolio in the world, prioritizing the most promising ideas and key studies to ensure that they continue on a strategic course forward.

Funding opportunities

The Foundation drives progress by awarding grants to ensure that the most promising research avenues are thoroughly funded, explored and carried forward toward pharmacy shelves.^[5] The Foundation's four annually recurring Pipeline Programs aim to speed research along the drug development pipeline.^[6] The Pipeline Programs include:

Rapid Response Innovation Awards quickly support high-risk, high-reward projects with little to no existing preliminary data, but potential to significantly impact our understanding or treatment of PD (an Edmond J. Safra Core Program for PD Research).

Target Validation Awards provide support for work demonstrating whether modulation of a novel biological target has impact in a PD-relevant pre-clinical model — an essential step to the development of potential targeted therapies (an Edmond J. Safra Core Program for PD Research).

Clinical Intervention Awards support clinical testing of promising PD therapies that may significantly and fundamentally improve treatment of PD (an Edmond J. Safra Core Program for PD Research).

Therapeutics Development Initiative, an industry-exclusive support program for preclinical development of Parkinson’s disease therapies with potential to fundamentally alter disease course and/or improve treatment of symptoms above and beyond current standards of care.

The Pipeline Programs are complemented by the Foundation's Critical Challenges in Parkinson's Disease program, which provides funds for top research priorities.^[7] Critical Challenges in 2009/2010 include: speeding research on PD genetic targets, LRRK2 and alpha-synuclein; advancing research on neurotrophic factors; identifying biomarkers of PD; understanding patient's unmet needs, like postural instability and gait disturbances; and, promoting collaborations with the Arizona Parkinson's Disease Consortium.

In September 2011, Nike has made limited edition shoes that were inspired by the second movie of Back To The Future. The proceeds were to go to the Michael J. Fox Foundation.^[8]

On September 26, 2012 Chris Cosentino – Incanto (San Francisco, CA) won season 4 and was crowned Top Chef: Master on the BRAVO TV Network. Chris's raised $141,000 for the Michael J. Fox Foundation for Parkinson's Research. ^[9]

Team Fox

Team Fox is The Michael J. Fox Foundation's grassroots community initiative to help raise funds and awareness for Parkinson's research. Launched in 2006, Team Fox members are running marathons, flipping pancakes, climbing mountains, hosting concerts, golfing for a cure and more.

Fox Trial Finder

Fox Trial Finder is a web-based matching tool that connects volunteers to Parkinson's clinical trials and makes it easy for patients and their loved ones to get involved in research.

Education and awareness

The Michael J. Fox Foundation publishes a print newsletter, The Fox Focus, two times per year as well as a monthly e-newsletter, FoxFlash, to keep supporters updated on Parkinson's research progress.^[10] In 2010, the Foundation launched an audio podcast series on Parkinson's science, hosted by KQED Public Radio Host David Iverson.^[11] Living with Parkinson's is the Foundation's online source for information on PD (including an animation about how the brain is affected by Parkinson's), guides for the newly diagnosed and caregivers, stories from people living with the disease and additional resources.^[12]

Fox Shop

Fox Shop is The Michael J. Fox Foundation's online store.^[13] Filled with apparel and accessories featuring the Foundation's fox logo, Fox Shop products support The Michael J. Fox Foundation.