Tetrahydroharman
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| Names | |
|---|---|
| Preferred IUPAC name
1-Methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole | |
| Systematic IUPAC name
1-Methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indole | |
| Other names
Elaeagnine Methtryptoline Tetrahydroharmane | |
| Identifiers | |
| 3DMet | B02674 |
525-40-6  23844-21-5 (1S)  2254-36-6 (1R) 2506-10-7 | |
| ChEBI | CHEBI:311872 |
| ChemSpider | 82643 614612 (1S) 390581 (1R) |
| EC number | 219-711-4 |
| |
| Jmol-3D images | Image |
| KEGG | C09089 |
| MeSH | Tetrahydroharmane |
| PubChem | 91522 () 704991 (1S) 442025 (1R) |
| |
| Properties | |
| C12H14N2 | |
| Molar mass | 186.25296 g/mol |
| Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
| verify (what is: /?) | |
| Infobox references | |
Tetrahydroharman(e), also known as 1-methyl-1,2,3,4-tetrahydro-β-carboline, is a general name for one of two isomers:
- (1S)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
- Calligonine ((1R)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole)
Calligonine is a major alkaloid constituent of the roots of Calligonum minimum and the bark of Elaeagnus angustifolia. When taken internally, it has the effect of substantially lowering blood pressure for an extended period of time, similar to reserpine.
References
- Landolt-Börnstein
- Badger, Geoffrey M.; A. F. Beecham (1951). "Isolation of Tetrahydroharman from Petalostyles labicheoides". Nature 168 (4273): 517–518. doi:10.1038/168517b0.
- Harborne, Jeffrey B.; Herbert Baxter and Gerard Moss (1999). Phytochemical Dictionary: A Handbook of Bioactive Compounds from Plants (2 ed.). CRC Press. p. 195. ISBN 0-7484-0620-4.
- Kar, Ashutosh (2003). Pharmacognosy and Pharmacobiotechnology. New Age Publishers. p. 580. ISBN 81-224-1501-6.