Terlipressin
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| Systematic (IUPAC) name | |
|---|---|
| 1-{[(4R,7S,10S,13S,16S,19R)-19-{[({[(aminoacetyl)amino]acetyl}amino)acetyl]amino}-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-N-(2-amino-2-oxoethyl)-L-lysinamide | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| IV | |
| Pharmacokinetic data | |
| Protein binding | ~30% |
| Identifiers | |
14636-12-5  | |
| H01BA04 | |
| PubChem | CID 72081 |
| DrugBank |
DB02638 |
| ChemSpider |
65067 |
| UNII |
7Z5X49W53P |
| KEGG |
D06672 |
| Chemical data | |
| Formula | C52H74N16O15S2 |
| 1227.37 g/mol | |
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SMILES
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| (what is this?) (verify) | |
Terlipressin (trade names Teripress by New Medicon Pharma and Glypressin by Ferring Pharmaceuticals) is an analogue of vasopressin used as a vasoactive drug in the management of low blood pressure. It has been found to be effective when norepinephrine does not help.
Indications for use include norepinephrine-resistant septic shock[1] and hepatorenal syndrome.[2] In addition, it is used to treat bleeding esophageal varices.[3]
Availability
Terlipressin is currently not available in the United States,[4] or Canada,[5] but it is available in New Zealand,[6] Australia, much of Europe,[7] India & UAE.
Contraindications
Must not be used during pregnancy.
See also
References
- ↑ O'Brien A, Clapp L, Singer M (2002). "Terlipressin for norepinephrine-resistant septic shock". Lancet 359 (9313): 1209–10. doi:10.1016/S0140-6736(02)08225-9. PMID 11955542.
- ↑ Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J (2000). "Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome". J Hepatol 33 (1): 43–8. doi:10.1016/S0168-8278(00)80158-0. PMID 10905585.
- ↑ Ioannou G, Doust J, Rockey D (2003). Ioannou, George N, ed. "Terlipressin for acute esophageal variceal hemorrhage". Cochrane Database Syst Rev (1): CD002147. doi:10.1002/14651858.CD002147. PMID 12535432.
- ↑ "{1} And {2} Report Fast Track Designation For Terlipressin In Type 1 Hepatorenal Syndrome - News, Search Jobs, Events".
- ↑ "Drug Product Search".
- ↑ http://www.medsafe.govt.nz/profs/datasheet/g/Glypressin01mgmlFerringinj.pdf
- ↑ http://www.drugs.com/international/terlipressin.html
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