Tennessee State Route 21
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| Route information | ||||
| Maintained by TDOT | ||||
| Major junctions | ||||
| West end: | Mississippi River near Tiptonville | |||
 SR 22 at Tiptonville SR 78 at Tiptonville US 51 at Troy US 45W in Union City | ||||
| East end: |
  KY 116 / KY 239 | |||
| Location | ||||
| Counties: | Obion, Lake | |||
| Highway system | ||||
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State Route 21 is a two lane highway that runs from the Mississippi River west of Tiptonville, Tennessee to the Kentucky state line north of Union City. This road provides access to Reelfoot Lake State Park.