Technetium (99mTc) exametazime

Technetium (99mTc) exametazime
Systematic (IUPAC) name
[[(3RS,3'RS)-3,3'-[(2,2-Dimethyltrimethylene)diimino][di-2-butanone]dioximato](3-)-N,N',N'',N''']oxotechnetium (99mTc)
Clinical data
Trade names Ceretec
Licence data US FDA:link
  • US: C (Risk not ruled out)
Intravenous
Identifiers

100551-63-1 (exametazime)
V09AA01
V09HA02 (labelled leucocytes)
PubChem CID 9552069
UNII 3B744AG22N Yes
Chemical data
Formula C13H25N4O3Tc
384.3655 g/mol
 Yes (what is this?)  (verify)

Technetium (99mTc) exametazime is a radiopharmaceutical sold under the trade name Ceretec, and is used for the detection of altered regional cerebral perfusion in stroke[1] and other cerebrovascular diseases. It can also be used for the labelling of leukocytes to localise intra-abdominal infections[2] and inflammatory bowel disease.[3] Exametazime (the part without technetium) is sometimes referred to by its chemical name of hexamethylpropyleneamine oxime or HMPAO.

Chemistry

Exametazime (hexamethylpropyleneamine oxime, HMPAO)

The drug consists of two of the three stereoisomers of hexametazime (HMPAO), one of which is shown here, the other being its enantiomer.[4] The third stereoisomer is the meso form. Exametazime acts as a chelating agent for the radioisotope technetium-99m.

References

  1. ↑ Moretti, J. L.; Defer, G.; Cinotti, L.; Cesaro, P.; Degos, J. D.; Vigneron, N.; Ducassou, D.; Holman, B. L. (1990). ""Luxury perfusion" with 99mTc-HMPAO and 123I-IMP SPECT imaging during the subacute phase of stroke". European journal of nuclear medicine 16 (1): 17–22. doi:10.1007/BF01566007. PMID 2307169.
  2. ↑ Weldon, M. J.; Joseph, A. E.; French, A.; Saverymuttu, S. H.; Maxwell, J. D. (1995). "Comparison of 99m technetium hexamethylpropylene-amine oxime labelled leucocyte with 111-indium tropolonate labelled granulocyte scanning and ultrasound in the diagnosis of intra-abdominal abscess". Gut 37 (4): 557–564. doi:10.1136/gut.37.4.557. PMC 1382910. PMID 7489945.
  3. ↑ Ui, K.; Yamaguchi, T. (1991). "Therapy and diagnosis of emergency shock patients". Nihon Naika Gakkai zasshi. the Journal of the Japanese Society of Internal Medicine 80 (12): 1892–1896. PMID 1804909.
  4. ↑ Monography in the European Pharmacopoeia

External links