TXNDC5
Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene.[1]
Function
This gene encodes a protein disulfide-isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. This gene can be co-transcribed with the upstream gene MUTED.[1]
References
Further reading
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Neve EP, Svensson K, Fuxe J, Pettersson RF (2003). "VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum". Exp. Cell Res. 288 (1): 70–83. doi:10.1016/S0014-4827(03)00161-7. PMID 12878160.
- Knoblach B; Keller BO; Groenendyk J et al. (2006). "ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins". Mol. Cell Proteomics 2 (10): 1104–19. doi:10.1074/mcp.M300053-MCP200. PMID 12930873.
- Sullivan DC; Huminiecki L; Moore JW et al. (2004). "EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor". J. Biol. Chem. 278 (47): 47079–88. doi:10.1074/jbc.M308124200. PMID 12963716.
- Clark HF; Gurney AL; Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Mungall AJ; Palmer SA; Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Bruneel A; Labas V; Mailloux A et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
- Nissom PM; Lo SL; Lo JC et al. (2006). "Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma". FEBS Lett. 580 (9): 2216–26. doi:10.1016/j.febslet.2006.03.029. PMID 16574106.
- Wang Y; Ma Y; Lü B et al. (2007). "Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study". Exp. Biol. Med. (Maywood) 232 (9): 1152–9. doi:10.3181/0701-RM-8. PMID 17895523.
PDB gallery |
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| | 2diz: The solution structure of the third thioredoxin domain of human Thioredoxin domain-containing protein 5 |
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