TWIST2
Twist-related protein 2 is a protein that in humans is encoded by the TWIST2 gene.[1][2][3]
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Twist. It is thought that during osteoblast development this protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype.[3]
Interactions
TWIST2 has been shown to interact with SREBF1.[4]
References
- ↑ Li L, Cserjesi P, Olson EN (Dec 1995). "Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis". Dev Biol 172 (1): 280–92. doi:10.1006/dbio.1995.0023. PMID 7589808.
- ↑ Perrin-Schmitt F, Bolcato-Bellemin AL, Bourgeois P, Stoetzel C, Danse JM (Apr 1997). "The locations of the H-twist and H-dermo-1 genes are distinct on the human genome". Biochim Biophys Acta 1360 (1): 1–2. doi:10.1016/s0925-4439(96)00071-3. PMID 9061034.
- ↑ 3.0 3.1 "Entrez Gene: TWIST2 twist homolog 2 (Drosophila)".
- ↑ Lee, Yun Sok; Lee Hyoung Ho; Park Jiyoung; Yoo Eung Jae; Glackin Carlotta A; Choi Young Il; Jeon Sung Ho; Seong Rho Hyun; Park Sang Dai; Kim Jae Bum (Dec 2003). "Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c". Nucleic Acids Res. (England) 31 (24): 7165–74. doi:10.1093/nar/gkg934. PMC 291873. PMID 14654692.
Further reading
- Volorio S, Simon G, Repetto M et al. (1999). "Sequencing analysis of forty-eight human image cDNA clones similar to Drosophila mutant protein". DNA Seq. 9 (5–6): 307–15. doi:10.3109/10425179809008469. PMID 10524757.
- Lee MS, Lowe G, Flanagan S et al. (2000). "Human Dermo-1 has attributes similar to twist in early bone development". Bone 27 (5): 591–602. doi:10.1016/S8756-3282(00)00380-X. PMID 11062344.
- Gong XQ, Li L (2002). "Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation". J. Biol. Chem. 277 (14): 12310–7. doi:10.1074/jbc.M110228200. PMID 11809751.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lee YS, Lee HH, Park J et al. (2004). "Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c". Nucleic Acids Res. 31 (24): 7165–74. doi:10.1093/nar/gkg934. PMC 291873. PMID 14654692.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Firulli BA, Krawchuk D, Centonze VE et al. (2005). "Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities". Nat. Genet. 37 (4): 373–81. doi:10.1038/ng1525. PMC 2568820. PMID 15735646.
- Raval A, Lucas DM, Matkovic JJ et al. (2005). "TWIST2 demonstrates differential methylation in immunoglobulin variable heavy chain mutated and unmutated chronic lymphocytic leukemia". J. Clin. Oncol. 23 (17): 3877–85. doi:10.1200/JCO.2005.02.196. PMID 15809452.
- Terauchi M, Kajiyama H, Yamashita M et al. (2007). "Possible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinoma". Clin. Exp. Metastasis 24 (5): 329–39. doi:10.1007/s10585-007-9070-1. PMID 17487558.
External links
- TWIST2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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