TUC338
| TUC338 | ||
|---|---|---|
| Identifiers | ||
| Symbol | TUC338 | |
| Other data | ||
| RNA type | Gene | |
| Domain(s) | Vertebrata | |
| Locus | Chr. 12 q | |
TUC338 (transcribed ultra-conserved region 338) is an ultra-conserved element which is transcribed to give a non-coding RNA.[1][2] The TUC338 gene was first identified as uc.338, along with 480 other ultra-conserved elements in the human genome.[3] Expression of this RNA gene has been found to dramatically increase in hepatocellular carcinoma (HCC) cells.[4]
The TUC338 RNA gene is 590 base-pairs long, and partially overlaps the gene encoding Poly(rC)-binding protein 2 (PCBP2), a protein involved in mRNA processing.[5] Despite this overlap, PCBP2 and TUC388 were found to be independently expressed.[4]
TUC338 is predicted to function in cell growth, possibly at the interface between G1 phase and S phase, and could potentially present a therapeutic target to treat HCC cells.[4] Experimental evidence shows knocking out TUC338 using siRNA reduced the growth rate of both mouse and human HCC cells.[4]
References
- ↑ Calin, GA; Liu, CG, Ferracin, M, Hyslop, T, Spizzo, R, Sevignani, C, Fabbri, M, Cimmino, A, Lee, EJ, Wojcik, SE, Shimizu, M, Tili, E, Rossi, S, Taccioli, C, Pichiorri, F, Liu, X, Zupo, S, Herlea, V, Gramantieri, L, Lanza, G, Alder, H, Rassenti, L, Volinia, S, Schmittgen, TD, Kipps, TJ, Negrini, M, Croce, CM (Sep 2007). "Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas.". Cancer Cell 12 (3): 215–29. doi:10.1016/j.ccr.2007.07.027. PMID 17785203.
- ↑ Bejerano G, Lowe CB, Ahituv N, King B, Siepel A, Salama SR, Rubin EM, Kent WJ, Haussler D (2006). "A distal enhancer and an ultraconserved exon are derived from a novel retroposon.". Nature 441 (7089): 87–90. doi:10.1038/nature04696. PMID 16625209.
- ↑ Bejerano, G; Pheasant, M; Makunin, I; Stephen, S; Kent, WJ; Mattick, JS; Haussler, D (2004-05-28). "Ultraconserved elements in the human genome.". Science 304 (5675): 1321–5. doi:10.1126/science.1098119. PMID 15131266.
- ↑ 4.0 4.1 4.2 4.3 Braconi, C; Valeri, N; Kogure, T; Gasparini, P; Huang, N; Nuovo, GJ; Terracciano, L; Croce, CM; Patel, T (2011-01-11). "Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma.". Proceedings of the National Academy of Sciences of the United States of America 108 (2): 786–91. doi:10.1073/pnas.1011098108. PMC 3021052. PMID 21187392. Retrieved 17 August 2011.
- ↑ Czyzyk-Krzeska, MF; Bendixen, AC (1999-03-15). "Identification of the poly(C) binding protein in the complex associated with the 3' untranslated region of erythropoietin messenger RNA.". Blood 93 (6): 2111–20. PMID 10068686.
External links
Further reading
- Yam, JW; Wong, CM, Ng, IO (2010-01-01). "Molecular and functional genetics of hepatocellular carcinoma.". Frontiers in bioscience (Scholar edition) 2: 117–34. PMID 20036934.