TUBB1
| Tubulin, beta 1 class VI | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TUBB1 ; dJ543J19.4 | ||||||||||||
| External IDs | OMIM: 612901 MGI: 107814 HomoloGene: 69474 ChEMBL: 1915 GeneCards: TUBB1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 81027 | 545486 | |||||||||||
| Ensembl | ENSG00000101162 | ENSMUSG00000016255 | |||||||||||
| UniProt | Q9H4B7 | A2AQ07 | |||||||||||
| RefSeq (mRNA) | NM_030773 | NM_001080971 | |||||||||||
| RefSeq (protein) | NP_110400 | NP_001074440 | |||||||||||
| Location (UCSC) | Chr 20: 57.59 – 57.6 Mb | Chr 2: 174.45 – 174.46 Mb | |||||||||||
| PubMed search | |||||||||||||
Tubulin beta-1 chain is a protein that in humans is encoded by the TUBB1 gene.[1]
References
Further reading
- Watts NR, Sackett DL, Ward RD et al. (2000). "HIV-1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings". J. Cell Biol. 150 (2): 349–60. doi:10.1083/jcb.150.2.349. PMC 2180222. PMID 10908577.
- Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Andersen JS, Lyon CE, Fox AH et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–10. doi:10.1093/emboj/cdf683. PMC 139103. PMID 12486001.
- Gevaert K, Goethals M, Martens L et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Yanagida M, Hayano T, Yamauchi Y et al. (2004). "Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes". J. Biol. Chem. 279 (3): 1607–14. doi:10.1074/jbc.M305604200. PMID 14583623.
- Dou Z, Ding X, Zereshki A et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2". FEBS Lett. 572 (1–3): 51–6. doi:10.1016/j.febslet.2004.06.092. PMID 15304323.
- Schulze H, Korpal M, Bergmeier W et al. (2005). "Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions". Blood 104 (13): 3949–57. doi:10.1182/blood-2004-03-1179. PMID 15315966.
- Campbell GR, Pasquier E, Watkins J et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197–204. doi:10.1074/jbc.M406195200. PMID 15331610.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- de Mareuil J, Carre M, Barbier P et al. (2006). "HIV-1 Tat protein enhances Microtubule polymerization". Retrovirology 2: 5. doi:10.1186/1742-4690-2-5. PMC 549075. PMID 15691386.
- Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology 2: 7. doi:10.1186/1742-4690-2-7. PMC 549042. PMID 15698476.
- Freson K, De Vos R, Wittevrongel C et al. (2005). "The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure". Blood 106 (7): 2356–62. doi:10.1182/blood-2005-02-0723. PMID 15956286.
- Mesquita B, Veiga I, Pereira D et al. (2006). "No significant role for beta tubulin mutations and mismatch repair defects in ovarian cancer resistance to paclitaxel/cisplatin". BMC Cancer 5: 101. doi:10.1186/1471-2407-5-101. PMC 1199587. PMID 16095531.
- Coiras M, Camafeita E, Ureña T et al. (2006). "Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression". Proteomics. 6 Suppl 1: S63–73. doi:10.1002/pmic.200500437. PMID 16526095.
- Navarro-Núñez L, Lozano ML, Rivera J et al. (2007). "The association of the beta1-tubulin Q43P polymorphism with intracerebral hemorrhage in men". Haematologica 92 (4): 513–8. doi:10.3324/haematol.10689. PMID 17488662.