TUBA8

Tubulin, alpha 8

PDB rendering based on 1tub.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1tub, 1tvk, 1z2b

Identifiers

TUBA8 ; TUBAL2

External IDs

OMIM: 605742 MGI: 1858225 HomoloGene: 56766 GeneCards: TUBA8 Gene

Gene ontology
Molecular function	• GTPase activity • structural constituent of cytoskeleton • GTP binding
Cellular component	• cytoplasm • microtubule
Biological process	• GTP catabolic process • microtubule-based process • protein polymerization
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000183785

ENSMUSG00000030137

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 22:
18.59 – 18.63 Mb

Chr 6:
121.21 – 121.23 Mb

PubMed search

Tubulin alpha-8 chain is a protein that in humans is encoded by the TUBA8 gene.^[1]^[2]^[3]^[4]

References

↑ Stanchi F, Corso V, Scannapieco P, Ievolella C, Negrisolo E, Tiso N, Lanfranchi G, Valle G (May 2000). "TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse". Biochem Biophys Res Commun 270 (3): 1111–8. doi:10.1006/bbrc.2000.2571. PMID 10772959.
↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
↑ "Entrez Gene: TUBA8 tubulin, alpha 8".
↑ "GeneCards: TUBA8 gene".

Further reading

Alexandrova N, Niklinski J, Bliskovsky V et al. (1995). "The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro.". Mol. Cell. Biol. 15 (9): 5188–95. PMC 230766. PMID 7651436.
Feierbach B, Nogales E, Downing KH, Stearns T (1999). "Alf1p, a CLIP-170 domain-containing protein, is functionally and physically associated with alpha-tubulin.". J. Cell Biol. 144 (1): 113–24. doi:10.1083/jcb.144.1.113. PMC 2148126. PMID 9885248.
Herreros L, Rodríguez-Fernandez JL, Brown MC et al. (2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton.". J. Biol. Chem. 275 (34): 26436–40. doi:10.1074/jbc.M003970200. PMID 10840040.
Watts NR, Sackett DL, Ward RD et al. (2000). "HIV-1 rev depolymerizes microtubules to form stable bilayered rings.". J. Cell Biol. 150 (2): 349–60. doi:10.1083/jcb.150.2.349. PMC 2180222. PMID 10908577.
Germani A, Bruzzoni-Giovanelli H, Fellous A et al. (2001). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis.". Oncogene 19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID 11146551.
Saugstad JA, Yang S, Pohl J et al. (2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin.". J. Neurochem. 80 (6): 980–8. doi:10.1046/j.0022-3042.2002.00778.x. PMC 2925652. PMID 11953448.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.". EMBO J. 21 (24): 6801–10. doi:10.1093/emboj/cdf683. PMC 139103. PMID 12486001.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Xu Y, Kulkosky J, Acheampong E et al. (2004). "HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy.". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 7070–5. doi:10.1073/pnas.0304859101. PMC 406467. PMID 15103018.
Campbell GR, Pasquier E, Watkins J et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis.". J. Biol. Chem. 279 (46): 48197–204. doi:10.1074/jbc.M406195200. PMID 15331610.
Collins JE, Wright CL, Edwards CA et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
de Mareuil J, Carre M, Barbier P et al. (2006). "HIV-1 Tat protein enhances microtubule polymerization.". Retrovirology 2: 5. doi:10.1186/1742-4690-2-5. PMC 549075. PMID 15691386.
Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology 2: 7. doi:10.1186/1742-4690-2-7. PMC 549042. PMID 15698476.
Valenzuela-Fernández A, Alvarez S, Gordon-Alonso M et al. (2006). "Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection.". Mol. Biol. Cell 16 (11): 5445–54. doi:10.1091/mbc.E05-04-0354. PMC 1266439. PMID 16148047.
Canani RB, De Marco G, Passariello A et al. (2006). "Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells.". AIDS 20 (1): 5–10. doi:10.1097/01.aids.0000198088.85572.68. PMID 16327313.

PDB gallery

1tub: TUBULIN ALPHA-BETA DIMER, ELECTRON DIFFRACTION

1tvk: The binding mode of epothilone A on a,b-tubulin by electron crystallography

1z2b: Tubulin-colchicine-vinblastine: stathmin-like domain complex