TUBA1B

Tubulin, alpha 1b

PDB rendering based on 1ffx.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2E4H

Identifiers

Symbols

TUBA1B ; K-ALPHA-1

External IDs

OMIM: 602530 MGI: 107804 HomoloGene: 134527 GeneCards: TUBA1B Gene

Gene ontology
Molecular function	• double-stranded RNA binding • GTPase activity • structural molecule activity • structural constituent of cytoskeleton • protein binding • GTP binding
Cellular component	• microtubule • cytoplasmic microtubule • extracellular vesicular exosome
Biological process	• microtubule cytoskeleton organization • GTP catabolic process • protein folding • microtubule-based process • cytoskeleton-dependent intracellular transport • cellular protein metabolic process • 'de novo' posttranslational protein folding • protein polymerization • cell division • cellular response to interleukin-4
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
49.52 – 49.53 Mb

Chr 15:
98.93 – 98.93 Mb

PubMed search

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.^[1]^[2]^[3]

Interactions

TUBA1B has been shown to interact with PIK3R1.^[4] Antibodies against tubulin alpha 1b can be used as markers for microtubules and spindles.^[5]

References

↑ Banerjee A (Jun 2002). "Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells". Biochem Biophys Res Commun 293 (1): 598–601. doi:10.1016/S0006-291X(02)00269-3. PMID 12054644.
↑ Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW (Jan 1984). "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions". Mol Cell Biol 3 (10): 1738–45. PMC 370035. PMID 6646120.
↑ "Entrez Gene: TUBA1B tubulin, alpha 1b".
↑ Kapeller, R; Toker A; Cantley L C; Carpenter C L (Oct 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". J. Biol. Chem. (UNITED STATES) 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. ISSN 0021-9258. PMID 7592789.
↑ http://www.genetex.com/WebPage/Product/PromotionDetail.aspx?Type=Promotion&PromotionID=178

Venter JC (1993). "Identification of new human receptor and transporter genes by high throughput cDNA (EST) sequencing.". J. Pharm. Pharmacol. 45. Suppl 1: 355–60. PMID 8098743.
Lopez-Fanarraga M, Avila J, Guasch A et al. (2002). "Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics.". J. Struct. Biol. 135 (2): 219–29. doi:10.1006/jsbi.2001.4386. PMID 11580271.
Kapeller R, Toker A, Cantley LC, Carpenter CL (1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin.". J. Biol. Chem. 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. PMID 7592789.
Alexandrova N, Niklinski J, Bliskovsky V et al. (1995). "The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro.". Mol. Cell. Biol. 15 (9): 5188–95. PMC 230766. PMID 7651436.
Szasz J, Yaffe MB, Sternlicht H (1993). "Site-directed mutagenesis of alpha-tubulin. Reductive methylation studies of the Lys 394 region.". Biophys. J. 64 (3): 792–802. doi:10.1016/S0006-3495(93)81440-1. PMC 1262393. PMID 8097117.
Baumann MH, Wisniewski T, Levy E et al. (1996). "C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type.". Biochem. Biophys. Res. Commun. 219 (1): 238–42. doi:10.1006/bbrc.1996.0211. PMID 8619814.
Gress TM, Müller-Pillasch F, Geng M et al. (1996). "A pancreatic cancer-specific expression profile.". Oncogene 13 (8): 1819–30. PMID 8895530.
Crépieux P, Kwon H, Leclerc N et al. (1997). "I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain.". Mol. Cell. Biol. 17 (12): 7375–85. PMC 232593. PMID 9372968.
Herreros L, Rodríguez-Fernandez JL, Brown MC et al. (2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton.". J. Biol. Chem. 275 (34): 26436–40. doi:10.1074/jbc.M003970200. PMID 10840040.
Watts NR, Sackett DL, Ward RD et al. (2000). "HIV-1 rev depolymerizes microtubules to form stable bilayered rings.". J. Cell Biol. 150 (2): 349–60. doi:10.1083/jcb.150.2.349. PMC 2180222. PMID 10908577.
Takeoka A, Shimizu M, Horio T (2001). "Identification of an alpha-tubulin mutant of fission yeast from gamma-tubulin-interacting protein screening: genetic evidence for alpha-/gamma-tubulin interaction.". J. Cell. Sci. 113. Pt 24: 4557–62. PMID 11082048.
Germani A, Bruzzoni-Giovanelli H, Fellous A et al. (2001). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis.". Oncogene 19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID 11146551.
Yokota S, Yanagi H, Yura T, Kubota H (2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle.". Eur. J. Biochem. 268 (17): 4664–73. doi:10.1046/j.1432-1327.2001.02393.x. PMID 11532003.
Rommelaere H, De Neve M, Neirynck K et al. (2001). "Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families.". J. Biol. Chem. 276 (44): 41023–8. doi:10.1074/jbc.M106591200. PMID 11535601.
Klein C, Kramer EM, Cardine AM et al. (2002). "Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau.". J. Neurosci. 22 (3): 698–707. PMID 11826099.
Saugstad JA, Yang S, Pohl J et al. (2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin.". J. Neurochem. 80 (6): 980–8. doi:10.1046/j.0022-3042.2002.00778.x. PMC 2925652. PMID 11953448.