TTK (gene)

TTK protein kinase

Rendering based on PDB 2ZMC.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2X9E, 2ZMC, 2ZMD, 3CEK, 3DBQ, 3GFW, 3H9F, 3HMN, 3HMO, 3HMP, 3VQU, 3W1F, 4B94, 4BHZ, 4BI0, 4BI1, 4BI2, 4C4E, 4C4F, 4C4G, 4C4H, 4C4I, 4C4J, 4H7X, 4H7Y, 4JS8, 4JT3

Identifiers

Symbols

TTK ; CT96; ESK; MPH1; MPS1; MPS1L1; PYT

External IDs

OMIM: 604092 MGI: 1194921 HomoloGene: 2489 IUPHAR: 2264 ChEMBL: 3983 GeneCards: TTK Gene

EC number

2.7.12.1

Gene ontology
Molecular function	• protein serine/threonine kinase activity • protein serine/threonine/tyrosine kinase activity • protein tyrosine kinase activity • protein binding • ATP binding
Cellular component	• spindle • membrane
Biological process	• spindle organization • mitotic spindle organization • mitotic spindle assembly checkpoint • positive regulation of cell proliferation • positive regulation of pathway-restricted SMAD protein phosphorylation • peptidyl-tyrosine phosphorylation • chromosome separation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
80.71 – 80.75 Mb

Chr 9:
83.83 – 83.87 Mb

PubMed search

Dual specificity protein kinase TTK is an enzyme that in humans is encoded by the TTK gene.^[1]^[2]

References

↑ Mills GB, Schmandt R, McGill M, Amendola A, Hill M, Jacobs K, May C, Rodricks AM, Campbell S, Hogg D (Aug 1992). "Expression of TTK, a novel human protein kinase, is associated with cell proliferation". J Biol Chem 267 (22): 16000–6. PMID 1639825.
↑ "Entrez Gene: TTK TTK protein kinase".

Hanks SK, Quinn AM (1991). "Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members". Meth. Enzymol. Methods in Enzymology 200: 38–62. doi:10.1016/0076-6879(91)00126-H. ISBN 978-0-12-182101-2. PMID 1956325.
Lindberg RA, Fischer WH, Hunter T (1993). "Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine". Oncogene 8 (2): 351–9. PMID 7678926.
Lauzé E; Stoelcker B; Luca FC et al. (1995). "Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase". EMBO J. 14 (8): 1655–63. PMC 398258. PMID 7737118.
Cahill DP; da Costa LT; Carson-Walter EB et al. (1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics 58 (2): 181–7. doi:10.1006/geno.1999.5831. PMID 10366450.
Weinmann AS; Yan PS; Oberley MJ et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
Stucke VM, Silljé HH, Arnaud L, Nigg EA (2002). "Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication". EMBO J. 21 (7): 1723–32. doi:10.1093/emboj/21.7.1723. PMC 125937. PMID 11927556.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu ST; Chan GK; Hittle JC et al. (2003). "Human MPS1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from Kinetochores". Mol. Biol. Cell 14 (4): 1638–51. doi:10.1091/mbc.02-05-0074. PMC 153128. PMID 12686615.
Fisk HA, Mattison CP, Winey M (2004). "Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression". Proc. Natl. Acad. Sci. U.S.A. 100 (25): 14875–80. doi:10.1073/pnas.2434156100. PMC 299837. PMID 14657364.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dou Z; Ding X; Zereshki A et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2". FEBS Lett. 572 (1–3): 51–6. doi:10.1016/j.febslet.2004.06.092. PMID 15304323.
Wei JH; Chou YF; Ou YH et al. (2005). "TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68". J. Biol. Chem. 280 (9): 7748–57. doi:10.1074/jbc.M410152200. PMID 15618221.
Camacho E; Beà S; Salaverría I et al. (2006). "Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma". Int. J. Cancer 118 (2): 357–63. doi:10.1002/ijc.21370. PMID 16080195.
Leng M; Chan DW; Luo H et al. (2006). "MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability". Proc. Natl. Acad. Sci. U.S.A. 103 (31): 11485–90. doi:10.1073/pnas.0601828103. PMC 1518802. PMID 16864798.
Bertheau P; Turpin E; Rickman DS et al. (2007). "Exquisite Sensitivity of TP53 Mutant and Basal Breast Cancers to a Dose-Dense Epirubicin−Cyclophosphamide Regimen". PLoS Med. 4 (3): e90. doi:10.1371/journal.pmed.0040090. PMC 1831731. PMID 17388661.
Zhu S, Wang W, Clarke DC, Liu X (2007). "Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling". J. Biol. Chem. 282 (25): 18327–38. doi:10.1074/jbc.M700636200. PMID 17452325.
Kanai M; Ma Z; Izumi H et al. (2007). "Physical and functional interaction between mortalin and Mps1 kinase". Genes Cells 12 (6): 797–810. doi:10.1111/j.1365-2443.2007.01091.x. PMID 17573779.
Mattison CP; Old WM; Steiner E et al. (2007). "Mps1 activation loop autophosphorylation enhances kinase activity". J. Biol. Chem. 282 (42): 30553–61. doi:10.1074/jbc.M707063200. PMID 17728254.

TTK (gene)

References

Further reading