TTC3

Tetratricopeptide repeat domain 3

Identifiers

TTC3 ; DCRR1; RNF105; TPRDIII

External IDs

OMIM: 602259 MGI: 1276539 HomoloGene: 2487 GeneCards: TTC3 Gene

Gene ontology
Molecular function	• ubiquitin-protein transferase activity • protein binding • zinc ion binding • ligase activity
Cellular component	• nucleus • nucleolus • mitochondrion • vacuole
Biological process	• ubiquitin-dependent protein catabolic process • negative regulation of cell morphogenesis involved in differentiation • negative regulation of neuron differentiation • protein K48-linked ubiquitination
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000182670

ENSMUSG00000040785

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 21:
38.45 – 38.58 Mb

Chr 16:
94.37 – 94.47 Mb

PubMed search

Tetratricopeptide repeat protein 3 is a protein that in humans is encoded by the TTC3 gene.^[1]^[2]

References

↑ Tsukahara F, Hattori M, Muraki T, Sakaki Y (Mar 1997). "Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2". J Biochem 120 (4): 820–7. doi:10.1093/oxfordjournals.jbchem.a021485. PMID 8947847.
↑ "Entrez Gene: TTC3 tetratricopeptide repeat domain 3".

Further reading

Ohira M; Ootsuyama A; Suzuki E et al. (1996). "Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21". DNA Res. 3 (1): 9–16. doi:10.1093/dnares/3.1.9. PMID 8724848.
Eki T; Abe M; Naitou M et al. (1997). "Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2". DNA Seq. 7 (3–4): 153–64. doi:10.3109/10425179709034031. PMID 9254009.
Dahmane N; Ghezala GA; Gosset P et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome". Genomics 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID 9503011.
Rachidi M; Lopes C; Gassanova S et al. (2000). "Regional and cellular specificity of the expression of TPRD, the tetratricopeptide Down syndrome gene, during human embryonic development". Mech. Dev. 93 (1–2): 189–93. doi:10.1016/S0925-4773(00)00259-8. PMID 10781955.
Hattori M; Fujiyama A; Taylor TD et al. (2000). "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Berto G; Camera P; Fusco C et al. (2007). "The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase". J. Cell. Sci. 120 (Pt 11): 1859–67. doi:10.1242/jcs.000703. PMID 17488780.