TSN (gene)

Translin

PDB rendering based on 1j1j.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsTSN ; BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN
External IDsOMIM: 600575 MGI: 109263 HomoloGene: 3397 GeneCards: TSN Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez724722099
EnsemblENSG00000211460ENSMUSG00000026374
UniProtQ15631Q62348
RefSeq (mRNA)NM_001261401NM_011650
RefSeq (protein)NP_001248330NP_035780
Location (UCSC)Chr 2:
122.49 – 122.53 Mb		Chr 1:
118.3 – 118.31 Mb
PubMed search

Translin is a protein that in humans is encoded by the TSN gene.[1][2][3]

Function

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.[3]

Interactions

TSN (gene) has been shown to interact with PPP1R15A.[4]

References

  1. ↑ Kasai M, Aoki K, Matsuo Y, Minowada J, Maziarz RT, Strominger JL (Dec 1994). "Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11)". Int Immunol 6 (7): 1017–25. doi:10.1093/intimm/6.7.1017. PMID 7947454.
  2. ↑ Aoki K, Inazawa J, Takahashi T, Nakahara K, Kasai M (Sep 1997). "Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein". Genomics 43 (2): 237–41. doi:10.1006/geno.1997.4796. PMID 9244443.
  3. ↑ 3.0 3.1 "Entrez Gene: TSN translin".
  4. ↑ Hasegawa T, Isobe K (1999). "Evidence for the interaction between Translin and GADD34 in mammalian cells". Biochim. Biophys. Acta 1428 (2-3): 161–8. doi:10.1016/s0304-4165(99)00060-4. PMID 10434033.

Further reading

  • Aoki K, Suzuki K, Sugano T et al. (1995). "A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations.". Nat. Genet. 10 (2): 167–74. doi:10.1038/ng0695-167. PMID 7663511.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Aoki K, Nakahara K, Ikegawa C et al. (1994). "Nuclear proteins binding to a novel target sequence within the recombination hotspot regions of Bcl-2 and the immunoglobulin DH gene family.". Oncogene 9 (4): 1109–15. PMID 8134113.
  • Aoki K, Ishida R, Kasai M (1997). "Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX.". FEBS Lett. 401 (2–3): 109–12. doi:10.1016/S0014-5793(96)01444-5. PMID 9013868.
  • Kasai M, Matsuzaki T, Katayanagi K et al. (1997). "The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome.". J. Biol. Chem. 272 (17): 11402–7. doi:10.1074/jbc.272.17.11402. PMID 9111049.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hasegawa T, Isobe K (1999). "Evidence for the interaction between Translin and GADD34 in mammalian cells.". Biochim. Biophys. Acta 1428 (2–3): 161–8. doi:10.1016/s0304-4165(99)00060-4. PMID 10434033.
  • Badge RM, Yardley J, Jeffreys AJ, Armour JA (2000). "Crossover breakpoint mapping identifies a subtelomeric hotspot for male meiotic recombination.". Hum. Mol. Genet. 9 (8): 1239–44. doi:10.1093/hmg/9.8.1239. PMID 10767349.
  • Hosaka T, Kanoe H, Nakayama T et al. (2001). "Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t(12;6).". Oncogene 19 (50): 5821–5. doi:10.1038/sj.onc.1203943. PMID 11126370.
  • Chennathukuzhi VM, Kurihara Y, Bray JD, Hecht NB (2001). "Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA.". J. Biol. Chem. 276 (16): 13256–63. doi:10.1074/jbc.M009707200. PMID 11278549.
  • Lee SP, Fuior E, Lewis MS, Han MK (2001). "Analytical ultracentrifugation studies of translin: analysis of protein-DNA interactions using a single-stranded fluorogenic oligonucleotide.". Biochemistry 40 (46): 14081–8. doi:10.1021/bi010302t. PMID 11705401.
  • Erdemir T, Bilican B, Oncel D et al. (2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX).". J. Cell. Sci. 115 (Pt 1): 207–16. PMID 11801738.
  • Han MK, Lin P, Paek D et al. (2002). "Fluorescence studies of pyrene maleimide-labeled translin: excimer fluorescence indicates subunits associate in a tail-to-tail configuration to form octamer.". Biochemistry 41 (10): 3468–76. doi:10.1021/bi015901e. PMID 11876655.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Sengupta K, Rao BJ (2003). "Translin binding to DNA: recruitment through DNA ends and consequent conformational transitions.". Biochemistry 41 (51): 15315–26. doi:10.1021/bi026378m. PMID 12484770.
  • Li K, Wang L, Cheng J et al. (2003). "Interaction between hepatitis C virus core protein and translin protein—a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus.". World J. Gastroenterol. 9 (2): 300–3. PMID 12532453.
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Yang S, Cho YS, Chennathukuzhi VM et al. (2004). "Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation.". J. Biol. Chem. 279 (13): 12605–14. doi:10.1074/jbc.M313133200. PMID 14711818.