TRIM33

Tripartite motif containing 33
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsTRIM33 ; ECTO; PTC7; RFG7; TF1G; TIF1G; TIF1GAMMA; TIFGAMMA
External IDsOMIM: 605769 MGI: 2137357 HomoloGene: 9296 IUPHAR: 2254 GeneCards: TRIM33 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez5159294093
EnsemblENSG00000197323ENSMUSG00000033014
UniProtQ9UPN9Q99PP7
RefSeq (mRNA)NM_015906NM_001079830
RefSeq (protein)NP_056990NP_001073299
Location (UCSC)Chr 1:
114.94 – 115.05 Mb		Chr 3:
103.28 – 103.36 Mb
PubMed search

Tripartite motif-containing 33 (TRIM33) also known as transcriptional intermediary factor 1 gamma (TIF1-γ), is a human gene.[1][2]

The protein encoded by this gene is thought to be a transcriptional corepressor. However unlike the related TIF1-α and TIF1-β proteins, few transcription factors such as Smad4 that interact with TIF1-γ have been identified.[1]

Structure

The protein is a member of the tripartite motif family.[3] This motif includes three zinc-binding domains:

and a coiled-coil region.

Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.[1]

Interactions

TRIM33 has been shown to interact with TRIM24.[4]

Role in cancer

TRIM33 acts as a tumor suppressor gene preventing the development chronic myelomonocytic leukemia.[5] TRIM33 acts as an oncogene by preventing apoptosis in B-cell leukemias.[6]

References

  1. ↑ 1.0 1.1 1.2 "Entrez Gene: TRIM33 tripartite motif-containing 33".
  2. ↑ Venturini L, You J, Stadler M, Galien R, Lallemand V, Koken MH, Mattei MG, Ganser A, Chambon P, Losson R, de Thé H (February 1999). "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene 18 (5): 1209–17. doi:10.1038/sj.onc.1202655. PMID 10022127.
  3. ↑ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  4. ↑ Peng, Hongzhuang; Feldman Irina; Rauscher Frank J (Jul 2002). "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". J. Mol. Biol. (England) 320 (3): 629–44. doi:10.1016/S0022-2836(02)00477-1. ISSN 0022-2836. PMID 12096914.
  5. ↑ PMID 21537084 (PubMed)
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  6. ↑ PMID 25919951 (PubMed)
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Further reading

  • Venturini L; You J; Stadler M et al. (1999). "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene 18 (5): 1209–17. doi:10.1038/sj.onc.1202655. PMID 10022127.
  • Klugbauer S, Rabes HM (1999). "The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas". Oncogene 18 (30): 4388–93. doi:10.1038/sj.onc.1202824. PMID 10439047.
  • Kikuno R; Nagase T; Ishikawa K et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  • Reymond A; Meroni G; Fantozzi A et al. (2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  • Peng H, Feldman I, Rauscher FJ (2002). "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". J. Mol. Biol. 320 (3): 629–44. doi:10.1016/S0022-2836(02)00477-1. PMID 12096914.
  • Yoon HG; Chan DW; Reynolds AB et al. (2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Mol. Cell 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
  • Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brandenberger R; Wei H; Zhang S et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
  • Dupont S; Zacchigna L; Cordenonsi M et al. (2005). "Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase". Cell 121 (1): 87–99. doi:10.1016/j.cell.2005.01.033. PMID 15820681.
  • Gregory SG; Barlow KF; McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
  • He W; Dorn DC; Erdjument-Bromage H et al. (2006). "Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway". Cell 125 (5): 929–41. doi:10.1016/j.cell.2006.03.045. PMID 16751102.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.