TRIM28
Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KAP1 (KRAB-associated protein-1), is a protein that in humans is encoded by the TRIM28 gene.[1][2]
Function
The protein encoded by this gene mediates transcriptional control by interaction with the Krüppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.[3]
Interactions
TRIM28 has been shown to interact with CBX5,[4][5][6][7] ZNF10,[8][9] CEBPB,[10][11] SETDB1[12] and Glucocorticoid receptor.[11]
See also
References
- ↑ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
- ↑ Capili AD, Schultz DC, RauscherIII FJ, Borden KL (January 2001). "Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains". EMBO J. 20 (1–2): 165–77. doi:10.1093/emboj/20.1.165. PMC 140198. PMID 11226167.
- ↑ "Entrez Gene: TRIM28 tripartite motif-containing 28".
- ↑ Nielsen, Anders Lade; Sanchez Cecilia; Ichinose Hiroshi; Cerviño Margarita; Lerouge Thierry; Chambon Pierre; Losson Régine (November 2002). "Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha". EMBO J. (England) 21 (21): 5797–806. doi:10.1093/emboj/cdf560. ISSN 0261-4189. PMC 131057. PMID 12411497.
- ↑ Cammas, Florence; Oulad-Abdelghani Mustapha, Vonesch Jean-Luc, Huss-Garcia Yolande, Chambon Pierre, Losson Régine (September 2002). "Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction". J. Cell. Sci. (England) 115 (Pt 17): 3439–48. ISSN 0021-9533. PMID 12154074.
- ↑ Nielsen, A L; Oulad-Abdelghani M; Ortiz J A; Remboutsika E; Chambon P; Losson R (April 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell (United States) 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. ISSN 1097-2765. PMID 11336697.
- ↑ Lechner, M S; Begg G E; Speicher D W; Rauscher F J (September 2000). "Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential". Mol. Cell. Biol. (UNITED STATES) 20 (17): 6449–65. doi:10.1128/MCB.20.17.6449-6465.2000. ISSN 0270-7306. PMC 86120. PMID 10938122.
- ↑ Moosmann, P; Georgiev O; Le Douarin B; Bourquin J P; Schaffner W (Dec 1996). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Res. (ENGLAND) 24 (24): 4859–67. doi:10.1093/nar/24.24.4859. ISSN 0305-1048. PMC 146346. PMID 9016654.
- ↑ Peng, H; Begg G E; Harper S L; Friedman J R; Speicher D W; Rauscher F J (June 2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain". J. Biol. Chem. (UNITED STATES) 275 (24): 18000–10. doi:10.1074/jbc.M001499200. ISSN 0021-9258. PMID 10748030.
- ↑ Rooney, J W; Calame K L (November 2001). "TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937". Genes Dev. (United States) 15 (22): 3023–38. doi:10.1101/gad.937201. ISSN 0890-9369. PMC 312827. PMID 12269264.
(Retracted. If this is intentional, please replace
{{Retracted}}with{{Retracted|intentional=yes}}.) - ↑ 11.0 11.1 Chang, C J; Chen Y L; Lee S C (October 1998). "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression". Mol. Cell. Biol. (UNITED STATES) 18 (10): 5880–7. ISSN 0270-7306. PMC 109174. PMID 9742105.
- ↑ Schultz, David C; Ayyanathan Kasirajan; Negorev Dmitri; Maul Gerd G; Rauscher Frank J (April 2002). "SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins". Genes Dev. (United States) 16 (8): 919–32. doi:10.1101/gad.973302. ISSN 0890-9369. PMC 152359. PMID 11959841.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Friedman JR; Fredericks WJ; Jensen DE et al. (1996). "KAP-1, a novel corepressor for the highly conserved KRAB repression domain". Genes Dev. 10 (16): 2067–78. doi:10.1101/gad.10.16.2067. PMID 8769649.
- Kim SS; Chen YM; O'Leary E et al. (1997). "A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15299–304. doi:10.1073/pnas.93.26.15299. PMC 26399. PMID 8986806.
- Moosmann P; Georgiev O; Le Douarin B et al. (1997). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Res. 24 (24): 4859–67. doi:10.1093/nar/24.24.4859. PMC 146346. PMID 9016654.
- Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Chang CJ, Chen YL, Lee SC (1998). "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression". Mol. Cell. Biol. 18 (10): 5880–7. PMC 109174. PMID 9742105.
- Eng FC; Barsalou A; Akutsu N et al. (1998). "Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain". J. Biol. Chem. 273 (43): 28371–7. doi:10.1074/jbc.273.43.28371. PMID 9774463.
- Ryan RF; Schultz DC; Ayyanathan K et al. (1999). "KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing". Mol. Cell. Biol. 19 (6): 4366–78. PMC 104396. PMID 10330177.
- Agata Y, Matsuda E, Shimizu A (1999). "Two novel Krüppel-associated box-containing zinc-finger proteins, KRAZ1 and KRAZ2, repress transcription through functional interaction with the corepressor KAP-1 (TIF1beta/KRIP-1)". J. Biol. Chem. 274 (23): 16412–22. doi:10.1074/jbc.274.23.16412. PMID 10347202.
- Nielsen AL; Ortiz JA; You J et al. (2000). "Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family". EMBO J. 18 (22): 6385–95. doi:10.1093/emboj/18.22.6385. PMC 1171701. PMID 10562550.
- Peng H; Begg GE; Harper SL et al. (2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain". J. Biol. Chem. 275 (24): 18000–10. doi:10.1074/jbc.M001499200. PMID 10748030.
- Lechner MS, Begg GE, Speicher DW, Rauscher FJ (2000). "Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential". Mol. Cell. Biol. 20 (17): 6449–65. doi:10.1128/MCB.20.17.6449-6465.2000. PMC 86120. PMID 10938122.
- Underhill C, Qutob MS, Yee SP, Torchia J (2001). "A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1". J. Biol. Chem. 275 (51): 40463–70. doi:10.1074/jbc.M007864200. PMID 11013263.
- Gebelein B, Urrutia R (2001). "Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Krüppel-associated box protein". Mol. Cell. Biol. 21 (3): 928–39. doi:10.1128/MCB.21.3.928-939.2001. PMC 86683. PMID 11154279.
- Capili AD, Schultz DC, RauscherIII FJ, Borden KL (2001). "Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains". EMBO J. 20 (1–2): 165–77. doi:10.1093/emboj/20.1.165. PMC 140198. PMID 11226167.
- Schultz DC, Friedman JR, Rauscher FJ (2001). "Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD". Genes Dev. 15 (4): 428–43. doi:10.1101/gad.869501. PMC 312636. PMID 11230151.
- Reymond A; Meroni G; Fantozzi A et al. (2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
- Hsu SI; Yang CM; Sim KG et al. (2001). "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1". EMBO J. 20 (9): 2273–85. doi:10.1093/emboj/20.9.2273. PMC 125435. PMID 11331592.
- Nielsen AL; Oulad-Abdelghani M; Ortiz JA et al. (2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. PMID 11336697.
- Rooney JW, Calame KL (2001). "TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937". Genes Dev. 15 (22): 3023–38. doi:10.1101/gad.937201. PMC 312827. PMID 11711437. (Retracted. If this is intentional, please replace
{{Retracted}}with{{Retracted|intentional=yes}}.)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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External links
- TRIM28 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C153
- FactorBook KAP1
- TRIM28 human gene location in the UCSC Genome Browser.
- TRIM28 human gene details in the UCSC Genome Browser.