TRAF3IP3
| TRAF3 interacting protein 3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | TRAF3IP3 ; T3JAM | ||||||||||
| External IDs | OMIM: 608255 MGI: 2441706 HomoloGene: 11885 GeneCards: TRAF3IP3 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 80342 | 215243 | |||||||||
| Ensembl | ENSG00000009790 | ENSMUSG00000037318 | |||||||||
| UniProt | Q9Y228 | Q8C0G2 | |||||||||
| RefSeq (mRNA) | NM_001287754 | NM_153137 | |||||||||
| RefSeq (protein) | NP_001274683 | NP_694777 | |||||||||
| Location (UCSC) | Chr 1: 209.93 – 209.96 Mb | Chr 1: 193.18 – 193.2 Mb | |||||||||
| PubMed search | |||||||||||
TRAF3-interacting JNK-activating modulator is a protein that in humans is encoded by the TRAF3IP3 gene.[1][2]
Model organisms
| Characteristic | Phenotype |
|---|---|
| Homozygote viability | Normal |
| Fertility | Normal |
| Body weight | Normal |
| Anxiety | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Hot plate | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Body temperature | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology | Abnormal[3] |
| Peripheral blood lymphocytes | Normal |
| Micronucleus test | Normal |
| Heart weight | Normal |
| Eye Histopathology | Normal |
| Salmonella infection | Normal[4] |
| Citrobacter infection | Abnormal[5] |
| All tests and analysis from[6][7] |
Model organisms have been used in the study of TRAF3IP3 function. A conditional knockout mouse line, called Traf3ip3tm1a(KOMP)Wtsi[8][9] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[10][11][12]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[6][13] Twenty three tests were carried out on homozygous mutant mice and two significant abnormalities were observed.[6] Males had a decrease in white blood cell count and females had an increased susceptibility to bacterial infection.[6]
Interactions
TRAF3IP3 has been shown to interact with STRN,[14] MOBKL3,[14] STK24[14] and FAM40A.[14]
References
- ↑ Dadgostar H, Doyle SE, Shahangian A, Garcia DE, Cheng G (Oct 2003). "T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1)". FEBS Lett 553 (3): 403–7. doi:10.1016/S0014-5793(03)01072-X. PMID 14572659.
- ↑ "Entrez Gene: TRAF3IP3 TRAF3 interacting protein 3".
- ↑ "Haematology data for Traf3ip3". Wellcome Trust Sanger Institute.
- ↑ "Salmonella infection data for Traf3ip3". Wellcome Trust Sanger Institute.
- ↑ "Citrobacter infection data for Traf3ip3". Wellcome Trust Sanger Institute.
- ↑ 6.0 6.1 6.2 6.3 Gerdin, AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
- ↑ "International Knockout Mouse Consortium".
- ↑ "Mouse Genome Informatics".
- ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
- ↑ Dolgin, Elie (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
- ↑ International Mouse Knockout Consortium; Collins, FS; Rossant, J; Wurst, W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
- ↑ 14.0 14.1 14.2 14.3 Goudreault, Marilyn; D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude (Jan 2009). "A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein". Mol. Cell Proteomics (United States) 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gregory SG; Barlow KF; McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Vasilescu J; Zweitzig DR; Denis NJ et al. (2007). "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells". J. Proteome Res. 6 (1): 298–305. doi:10.1021/pr060438j. PMID 17203973.
- Zhang C, Xie L, Cheng H, Wang Y (2007). "TRAF3 interacts with Smac/DIABLO and enhances the proapoptotic effect of Smac/DIABLO in cytoplasm". Acta Biochim. Biophys. Sin. (Shanghai) 39 (2): 108–16. doi:10.1111/j.1745-7270.2007.00259.x. PMID 17277885.
- Ma X; Wang X; Gao X et al. (2007). "Identification of five human novel genes associated with cell proliferation by cell-based screening from an expressed cDNA ORF library". Life Sci. 81 (14): 1141–51. doi:10.1016/j.lfs.2007.08.006. PMID 17868742.