TPM2
| Tropomyosin 2 (beta) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TPM2 ; AMCD1; DA1; DA2B; HEL-S-273; NEM4; TMSB | ||||||||||||
| External IDs | OMIM: 190990 MGI: 98810 HomoloGene: 134045 GeneCards: TPM2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7169 | 22004 | |||||||||||
| Ensembl | ENSG00000198467 | ENSMUSG00000028464 | |||||||||||
| UniProt | P07951 | P58774 | |||||||||||
| RefSeq (mRNA) | NM_001145822 | NM_001277875 | |||||||||||
| RefSeq (protein) | NP_001288155 | NP_001264804 | |||||||||||
| Location (UCSC) | Chr 9: 35.68 – 35.69 Mb | Chr 4: 43.51 – 43.52 Mb | |||||||||||
| PubMed search | |||||||||||||
Tropomyosin beta chain is a protein that in humans is encoded by the TPM2 gene.[1][2]
Interactions
TPM2 has been shown to interact with RRAD,[3] PDLIM7[4] and TPM1.[5]
References
- ↑ Hunt CC, Eyre HJ, Akkari PA, Meredith C, Dorosz SM, Wilton SD, Callen DF, Laing NG, Baker E (Aug 1995). "Assignment of the human beta tropomyosin gene (TPM2) to band 9p13 by fluorescence in situ hybridisation". Cytogenet Cell Genet 71 (1): 94–95. doi:10.1159/000134070. PMID 7606936.
- ↑ "Entrez Gene: TPM2 tropomyosin 2 (beta)".
- ↑ Zhu, J; Bilan P J; Moyers J S; Antonetti D A; Kahn C R (Jan 1996). "Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin". J. Biol. Chem. (UNITED STATES) 271 (2): 768–773. doi:10.1074/jbc.271.2.768. ISSN 0021-9258. PMID 8557685.
- ↑ Guy, P M; Kenny D A; Gill G N (Jun 1999). "The PDZ domain of the LIM protein enigma binds to beta-tropomyosin". Mol. Biol. Cell (UNITED STATES) 10 (6): 1973–84. doi:10.1091/mbc.10.6.1973. ISSN 1059-1524. PMC 25398. PMID 10359609.
- ↑ Brown, H R; Schachat F H (Apr 1985). "Renaturation of skeletal muscle tropomyosin: implications for in vivo assembly". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 82 (8): 2359–2363. doi:10.1073/pnas.82.8.2359. ISSN 0027-8424. PMC 397557. PMID 3857586.
External links
Further reading
- Gunning P, Weinberger R, Jeffrey P (1997). "Actin and tropomyosin isoforms in morphogenesis". Anat. Embryol. 195 (4): 311–315. doi:10.1007/s004290050050. PMID 9108196.
- Holtzer ME, Kidd SG, Crimmins DL, Holtzer A (1993). "Beta beta homodimers exist in native rabbit skeletal muscle tropomyosin and increase after denaturation-renaturation". Protein Sci. 1 (3): 335–341. doi:10.1002/pro.5560010305. PMC 2142203. PMID 1304342.
- Höner B, Shoeman RL, Traub P (1992). "Degradation of cytoskeletal proteins by the human immunodeficiency virus type 1 protease". Cell Biol. Int. Rep. 16 (7): 603–612. doi:10.1016/S0309-1651(06)80002-0. PMID 1516138.
- Chevray PM, Nathans D (1992). "Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5789–5793. doi:10.1073/pnas.89.13.5789. PMC 402103. PMID 1631061.
- Prasad GL, Meissner S, Sheer DG, Cooper HL (1991). "A cDNA encoding a muscle-type tropomyosin cloned from a human epithelial cell line: identity with human fibroblast tropomyosin TM1". Biochem. Biophys. Res. Commun. 177 (3): 1068–1075. doi:10.1016/0006-291X(91)90647-P. PMID 2059197.
- Libri D, Mouly V, Lemonnier M, Fiszman MY (1990). "A nonmuscle tropomyosin is encoded by the smooth/skeletal beta-tropomyosin gene and its RNA is transcribed from an internal promoter". J. Biol. Chem. 265 (6): 3471–3. PMID 2303454.
- Widada JS, Ferraz C, Capony JP, Liautard JP (1988). "Complete nucleotide sequence of the adult skeletal isoform of human skeletal muscle beta-tropomyosin". Nucleic Acids Res. 16 (7): 3109–3109. doi:10.1093/nar/16.7.3109. PMC 336462. PMID 3368322.
- Brown HR, Schachat FH (1985). "Renaturation of skeletal muscle tropomyosin: implications for in vivo assembly". Proc. Natl. Acad. Sci. U.S.A. 82 (8): 2359–2363. doi:10.1073/pnas.82.8.2359. PMC 397557. PMID 3857586.
- MacLeod AR; Houlker C; Reinach FC et al. (1986). "A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism". Proc. Natl. Acad. Sci. U.S.A. 82 (23): 7835–7839. doi:10.1073/pnas.82.23.7835. PMC 390864. PMID 3865200.
- Gimona M, Watakabe A, Helfman DM (1995). "Specificity of dimer formation in tropomyosins: influence of alternatively spliced exons on homodimer and heterodimer assembly". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9776–9780. doi:10.1073/pnas.92.21.9776. PMC 40885. PMID 7568216.
- Bamshad M; Watkins WS; Zenger RK et al. (1994). "A gene for distal arthrogryposis type I maps to the pericentromeric region of chromosome 9". Am. J. Hum. Genet. 55 (6): 1153–8. PMC 1918435. PMID 7977374.
- Takenaga K; Nakamura Y; Sakiyama S et al. (1994). "Binding of pEL98 protein, an S100-related calcium-binding protein, to nonmuscle tropomyosin". J. Cell Biol. 124 (5): 757–768. doi:10.1083/jcb.124.5.757. PMC 2119958. PMID 8120097.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Shoeman RL; Sachse C; Höner B et al. (1993). "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin". Am. J. Pathol. 142 (1): 221–30. PMC 1886840. PMID 8424456.
- Zhu J; Bilan PJ; Moyers JS et al. (1996). "Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin". J. Biol. Chem. 271 (2): 768–773. doi:10.1074/jbc.271.2.768. PMID 8557685.
- Tiso N; Rampoldi L; Pallavicini A et al. (1997). "Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast". Biochem. Biophys. Res. Commun. 230 (2): 347–350. doi:10.1006/bbrc.1996.5958. PMID 9016781.
- Gimona M; Lando Z; Dolginov Y et al. (1997). "Ca2+-dependent interaction of S100A2 with muscle and nonmuscle tropomyosins". J. Cell. Sci. 110 (5): 611–21. PMID 9092943.
- Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
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