TOP1

Topoisomerase (DNA) I

PDB rendering based on 1a31.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsTOP1 ; TOPI
External IDsOMIM: 126420 MGI: 98788 HomoloGene: 2467 IUPHAR: 2636 ChEMBL: 1781 GeneCards: TOP1 Gene
EC number5.99.1.2
Orthologs
SpeciesHumanMouse
Entrez715021969
EnsemblENSG00000198900ENSMUSG00000070544
UniProtP11387Q04750
RefSeq (mRNA)NM_003286NM_009408
RefSeq (protein)NP_003277NP_033434
Location (UCSC)Chr 20:
39.66 – 39.75 Mb		Chr 2:
160.65 – 160.72 Mb
PubMed search

DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene.

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.[1]

Interactions

TOP1 has been shown to interact with BTBD1,[2] P53,[3][4] Nucleolin,[5][6] BTBD2,[2] ASF/SF2[7][8] and UBE2I.[9]

See also

References

  1. ↑ "Entrez Gene: TOP1 topoisomerase (DNA) I".
  2. ↑ 2.0 2.1 Xu, Lixin; Yang Lihong, Hashimoto Keiko, Anderson Melvin, Kohlhagen Glenda, Pommier Yves, D'Arpa Peter (2002). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics (England) 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781. PMID 11818025.
  3. ↑ Gobert, C; Skladanowski A; Larsen A K (August 1999). "The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (18): 10355–60. doi:10.1073/pnas.96.18.10355. ISSN 0027-8424. PMC 17892. PMID 10468612.
  4. ↑ Mao, Yinghui; Mehl Issac R; Muller Mark T (February 2002). "Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (3): 1235–40. doi:10.1073/pnas.022631899. ISSN 0027-8424. PMC 122173. PMID 11805286.
  5. ↑ Haluska, P; Saleem A; Edwards T K; Rubin E H (April 1998). "Interaction between the N-terminus of human topoisomerase I and SV40 large T antigen". Nucleic Acids Res. (ENGLAND) 26 (7): 1841–7. doi:10.1093/nar/26.7.1841. ISSN 0305-1048. PMC 147454. PMID 9512561.
  6. ↑ Bharti, A K; Olson M O; Kufe D W; Rubin E H (January 1996). "Identification of a nucleolin binding site in human topoisomerase I". J. Biol. Chem. (UNITED STATES) 271 (4): 1993–7. doi:10.1074/jbc.271.4.1993. ISSN 0021-9258. PMID 8567649.
  7. ↑ Labourier, E; Rossi F; Gallouzi I E; Allemand E; Divita G; Tazi J (June 1998). "Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factor". Nucleic Acids Res. (ENGLAND) 26 (12): 2955–62. doi:10.1093/nar/26.12.2955. ISSN 0305-1048. PMC 147637. PMID 9611241.
  8. ↑ Andersen, Félicie F; Tange Thomas Ø; Sinnathamby Thayaline; Olesen Jens R; Andersen Kirsten E; Westergaard Ole; Kjems Jørgen; Knudsen Birgitta R (September 2002). "The RNA splicing factor ASF/SF2 inhibits human topoisomerase I mediated DNA relaxation". J. Mol. Biol. (England) 322 (4): 677–86. doi:10.1016/S0022-2836(02)00815-X. ISSN 0022-2836. PMID 12270705.
  9. ↑ Mao, Y; Sun M; Desai S D; Liu L F (April 2000). "SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (8): 4046–51. doi:10.1073/pnas.080536597. ISSN 0027-8424. PMC 18143. PMID 10759568.

Further reading