TOMM70A

Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)

Identifiers

TOMM70A ; FLJ90470

External IDs

OMIM: 606081 MGI: 106295 HomoloGene: 40112 GeneCards: TOMM70A Gene

Gene ontology
Molecular function	• protein binding • protein transmembrane transporter activity
Cellular component	• mitochondrion • mitochondrial outer membrane translocase complex • membrane • integral component of membrane
Biological process	• protein targeting to mitochondrion • cellular protein metabolic process • protein transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000154174

ENSMUSG00000022752

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
100.08 – 100.12 Mb

Chr 16:
57.12 – 57.15 Mb

PubMed search

Mitochondrial import receptor subunit TOM70 is a protein that in humans is encoded by the TOMM70A gene.^[1]^[2]

The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. See TIM17A (MIM 605057).[supplied by OMIM]^[2]

References

↑ Alvarez-Dolado M, Gonzalez-Moreno M, Valencia A, Zenke M, Bernal J, Munoz A (Dec 1999). "Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions". J Neurochem 73 (6): 2240–9. doi:10.1046/j.1471-4159.1999.0732240.x. PMID 10582581.
↑ 2.0 2.1 "Entrez Gene: TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)".

See Also

Further reading

Nagase T, Ishikawa K, Suyama M et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Edmonson AM, Mayfield DK, Vervoort V et al. (2002). "Characterization of a human import component of the mitochondrial outer membrane, TOMM70A". Cell Commun. Adhes. 9 (1): 15–27. doi:10.1080/15419060212186. PMID 12200962.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Young JC, Hoogenraad NJ, Hartl FU (2003). "Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70". Cell 112 (1): 41–50. doi:10.1016/S0092-8674(02)01250-3. PMID 12526792.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Humphries AD, Streimann IC, Stojanovski D et al. (2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40". J. Biol. Chem. 280 (12): 11535–43. doi:10.1074/jbc.M413816200. PMID 15644312.
Otsuki T, Ota T, Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Chou CH, Lee RS, Yang-Yen HF (2006). "An Internal EELD Domain Facilitates Mitochondrial Targeting of Mcl-1 via a Tom70-dependent Pathway". Mol. Biol. Cell 17 (9): 3952–63. doi:10.1091/mbc.E06-04-0319. PMC 1593170. PMID 16822835.
Fan AC, Bhangoo MK, Young JC (2006). "Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import". J. Biol. Chem. 281 (44): 33313–24. doi:10.1074/jbc.M605250200. PMID 16968702.