TNP2

Transition protein 2 (during histone to protamine replacement)
Identifiers
SymbolsTNP2 ; TP2
External IDsOMIM: 190232 MGI: 98785 HomoloGene: 3958 GeneCards: TNP2 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez714221959
EnsemblENSG00000178279ENSMUSG00000043050
UniProtQ05952P11378
RefSeq (mRNA)NM_005425NM_013694
RefSeq (protein)NP_005416NP_038722
Location (UCSC)Chr 16:
11.36 – 11.36 Mb		Chr 16:
10.79 – 10.79 Mb
PubMed search

Nuclear transition protein 2 is a protein that in humans is encoded by the TNP2 gene.[1][2][3]

References

  1. ↑ Engel W, Keime S, Kremling H, Hameister H, Schluter G (Nov 1992). "The genes for protamine 1 and 2 (PRM1 and PRM2) and transition protein 2 (TNP2) are closely linked in the mammalian genome". Cytogenet Cell Genet 61 (2): 158–9. doi:10.1159/000133397. PMID 1395729.
  2. ↑ Baskaran R, Rao MR (Jan 1991). "Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1". J Biol Chem 265 (34): 21039–47. PMID 2250010.
  3. ↑ "Entrez Gene: TNP2 transition protein 2 (during histone to protamine replacement)".

Further reading

  • Schlüter G, Kremling H, Engel W (1992). "The gene for human transition protein 2: nucleotide sequence, assignment to the protamine gene cluster, and evidence for its low expression.". Genomics 14 (2): 377–83. doi:10.1016/S0888-7543(05)80229-0. PMID 1385303.
  • Kundu TK, Rao MR (1995). "DNA condensation by the rat spermatidal protein TP2 shows GC-rich sequence preference and is zinc dependent.". Biochemistry 34 (15): 5143–50. doi:10.1021/bi00015a027. PMID 7711033.
  • Nelson JE, Krawetz SA (1995). "Characterization of a human locus in transition.". J. Biol. Chem. 269 (49): 31067–73. PMID 7983046.
  • Nelson JE, Krawetz SA (1993). "Linkage of human spermatid-specific basic nuclear protein genes. Definition and evolution of the P1-->P2-->TP2 locus.". J. Biol. Chem. 268 (4): 2932–6. PMID 8428967.
  • Kundu TK, Rao MR (1997). "Zinc dependent recognition of a human CpG island sequence by the mammalian spermatidal protein TP2.". Biochemistry 35 (49): 15626–32. doi:10.1021/bi961271i. PMID 8961924.
  • Steger K; Klonisch T; Gavenis K et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis". Mol. Hum. Reprod. 4 (10): 939–45. doi:10.1093/molehr/4.10.939. PMID 9809674.
  • Wyckoff GJ, Wang W, Wu CI (2000). "Rapid evolution of male reproductive genes in the descent of man". Nature 403 (6767): 304–9. doi:10.1038/35002070. PMID 10659848.
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wykes SM, Krawetz SA (2003). "The structural organization of sperm chromatin". J. Biol. Chem. 278 (32): 29471–7. doi:10.1074/jbc.M304545200. PMID 12775710.
  • Miyagawa Y; Nishimura H; Tsujimura A et al. (2006). "Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations". J. Androl. 26 (6): 779–86. doi:10.2164/jandrol.05069. PMID 16291974.
  • Jedrzejczak P; Kempisty B; Bryja A et al. (2007). "Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men". Arch. Androl. 53 (4): 199–205. doi:10.1080/01485010701426430. PMID 17852044.