TNNI1

Troponin I type 1 (skeletal, slow)

Identifiers

TNNI1 ; SSTNI; TNN1

External IDs

OMIM: 191042 MGI: 105073 HomoloGene: 2462 GeneCards: TNNI1 Gene

Gene ontology
Molecular function	• actin binding • metal ion binding
Cellular component	• cytosol • troponin complex
Biological process	• regulation of striated muscle contraction • muscle filament sliding • ventricular cardiac muscle tissue morphogenesis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
201.37 – 201.4 Mb

Chr 1:
135.78 – 135.81 Mb

PubMed search

Troponin I, slow skeletal muscle is a protein that in humans is encoded by the TNNI1 gene.^[1]^[2]^[3] It is a tissue-specific subtype of troponin I, which in turn is a part of the troponin complex.

References

↑ Wade R, Eddy R, Shows TB, Kedes L (Aug 1990). "cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I". Genomics 7 (3): 346–57. doi:10.1016/0888-7543(90)90168-T. PMID 2365354.
↑ Corin SJ, Juhasz O, Zhu L, Conley P, Kedes L, Wade R (May 1994). "Structure and expression of the human slow twitch skeletal muscle troponin I gene". J Biol Chem 269 (14): 10651–9. PMID 8144655.
↑ "Entrez Gene: TNNI1 troponin I type 1 (skeletal, slow)".

Hunkeler NM, Kullman J, Murphy AM (1991). "Troponin I isoform expression in human heart.". Circ. Res. 69 (5): 1409–14. doi:10.1161/01.res.69.5.1409. PMID 1934363.
Bhavsar PK, Dhoot GK, Cumming DV et al. (1992). "Developmental expression of troponin I isoforms in fetal human heart.". FEBS Lett. 292 (1-2): 5–8. doi:10.1016/0014-5793(91)80820-S. PMID 1959627.
Suzuki H, Kawarabayasi Y, Kondo J et al. (1990). "Structure and regulation of rat long-chain acyl-CoA synthetase.". J. Biol. Chem. 265 (15): 8681–5. PMID 2341402.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Jha PK, Leavis PC, Sarkar S (1997). "Interaction of deletion mutants of troponins I and T: COOH-terminal truncation of troponin T abolishes troponin I binding and reduces Ca2+ sensitivity of the reconstituted regulatory system.". Biochemistry 35 (51): 16573–80. doi:10.1021/bi9622433. PMID 8987992.
Tiso N, Rampoldi L, Pallavicini A et al. (1997). "Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast.". Biochem. Biophys. Res. Commun. 230 (2): 347–50. doi:10.1006/bbrc.1996.5958. PMID 9016781.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Jha PK, Sarkar S (1998). "A recombinant monocysteine mutant (Ser to Cys-155) of fast skeletal troponin T: identification by cross-linking of a domain involved in a physiologically relevant interaction with troponins C and I.". Biochemistry 37 (35): 12253–60. doi:10.1021/bi980025z. PMID 9724539.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Lindhout DA, Li MX, Schieve D, Sykes BD (2002). "Effects of T142 phosphorylation and mutation R145G on the interaction of the inhibitory region of human cardiac troponin I with the C-domain of human cardiac troponin C.". Biochemistry 41 (23): 7267–74. doi:10.1021/bi020100c. PMID 12044157.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Westfall MV, Borton AR (2003). "Role of troponin I phosphorylation in protein kinase C-mediated enhanced contractile performance of rat myocytes.". J. Biol. Chem. 278 (36): 33694–700. doi:10.1074/jbc.M305404200. PMID 12815045.
Polly P, Haddadi LM, Issa LL et al. (2003). "hMusTRD1alpha1 represses MEF2 activation of the troponin I slow enhancer.". J. Biol. Chem. 278 (38): 36603–10. doi:10.1074/jbc.M212814200. PMID 12857748.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Thijssen VL, Ausma J, Gorza L et al. (2005). "Troponin I isoform expression in human and experimental atrial fibrillation.". Circulation 110 (7): 770–5. doi:10.1161/01.CIR.0000138849.03311.C6. PMID 15289369.
Brobbey A, Ravakhah K (2004). "Elevated serum cardiac troponin I level in a patient after a grand mal seizure and with no evidence of cardiac disease.". Am. J. Med. Sci. 328 (3): 189–91. doi:10.1097/00000441-200409000-00012. PMID 15367881.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Proteins of the cytoskeleton

Human

Microfilaments
(ABPs)

Myofilament

Actins	A1 A2 B C1 G1 G2

Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1

Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Wiskott-Aldrich syndrome protein
Fibrillin
Filamin
- FLNA
- FLNB
- FLNC
Espin
TRIOBP

IFs

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 7 8 9

Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86

Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80

Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Lamin A
B

Microtubules/
MAPs

Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3

Dyneins	axonemal: DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3

Other	Tau protein Dynactin DCTN1 Tubulins TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3

Catenins

Membrane

Dystrophin
- Dystroglycan
Utrophin
Ankyrin
- ANK1
- ANK2
- ANK3
Spectrin
- SPTA1
- SPTAN1
- SPTB
- SPTBN1
- SPTBN2
- SPTBN4
- SPTBN5

Other

Nonhuman

See also: cytoskeletal defects

Index of cells

Description	Structure nucleus chromosome genetics Organelles peroxisome cytoskeleton centrosome epithelia cilia mitochondria Membranes proteins cell adhesions Membrane transport ion channels vesicular transport solute carrier ABC transporters ATPase oxidoreduction-driven

Disease	Structural peroxisome cytoskeleton cilia mitochondria nucleus scleroprotein Membrane channelopathy solute carrier ATPase ABC transporters other extracellular ligands cell surface receptors intracellular signalling Vesicular transport Pore-forming toxins

TNNI1

References

Further reading