TMF1

TATA element modulatory factor 1

Identifiers

TMF1 ; ARA160; TMF

External IDs

OMIM: 601126 MGI: 2684999 HomoloGene: 133801 GeneCards: TMF1 Gene

Gene ontology
Molecular function	• DNA binding • transcription cofactor activity • protein binding
Cellular component	• Golgi membrane • nucleus • endoplasmic reticulum • Golgi apparatus
Biological process	• acrosome assembly • positive regulation of cytokine production • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • spermatid nucleus differentiation • negative regulation of gene expression • sperm motility • luteinizing hormone secretion • Leydig cell differentiation • defense response to bacterium • negative regulation of apoptotic process • regulation of proteasomal protein catabolic process • cellular response to organic cyclic compound • positive regulation of testosterone secretion
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000144747

ENSMUSG00000030059

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
69.07 – 69.1 Mb

Chr 6:
97.16 – 97.18 Mb

PubMed search

TATA element modulatory factor is a protein that in humans is encoded by the TMF1 gene.^[1]^[2]

Interactions

TMF1 has been shown to interact with FER^[3] and Androgen receptor.^[4]

References

↑ Garcia JA, Ou SH, Wu F, Lusis AJ, Sparkes RS, Gaynor RB (Nov 1992). "Cloning and chromosomal mapping of a human immunodeficiency virus 1 "TATA" element modulatory factor". Proc Natl Acad Sci U S A 89 (20): 9372–6. doi:10.1073/pnas.89.20.9372. PMC 50133. PMID 1409643.
↑ "Entrez Gene: TMF1 TATA element modulatory factor 1".
↑ Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. (NETHERLANDS) 434 (3): 339–45. doi:10.1016/S0014-5793(98)01003-5. ISSN 0014-5793. PMID 9742951.
↑ Hsiao, P W; Chang C (Aug 1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. (UNITED STATES) 274 (32): 22373–9. doi:10.1074/jbc.274.32.22373. ISSN 0021-9258. PMID 10428808.

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Schwartz Y, Ben-Dor I, Navon A et al. (1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. 434 (3): 339–45. doi:10.1016/S0014-5793(98)01003-5. PMID 9742951.
Hsiao PW, Chang C (1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. 274 (32): 22373–9. doi:10.1074/jbc.274.32.22373. PMID 10428808.
Mori K, Kato H (2002). "A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus". FEBS Lett. 520 (1–3): 127–32. doi:10.1016/S0014-5793(02)02803-X. PMID 12044884.
Zhang Y, Fondell JD, Wang Q et al. (2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene 21 (36): 5609–18. doi:10.1038/sj.onc.1205638. PMID 12165860.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Fridmann-Sirkis Y, Siniossoglou S, Pelham HR (2004). "TMF is a golgin that binds Rab6 and influences Golgi morphology". BMC Cell Biol. 5: 18. doi:10.1186/1471-2121-5-18. PMC 419336. PMID 15128430.
Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Beausoleil SA, Villén J, Gerber SA et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Yamane J, Kubo A, Nakayama K et al. (2007). "Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic". Exp. Cell Res. 313 (16): 3472–85. doi:10.1016/j.yexcr.2007.07.010. PMID 17698061.