TIA1
| TIA1 cytotoxic granule-associated RNA binding protein | |
|---|---|
| Identifiers | |
| Symbol | TIA1 |
| Entrez | 7072 |
| HUGO | 11802 |
| OMIM | 603518 |
| RefSeq | NM_022173 |
| UniProt | P31483 |
| Other data | |
| Locus | Chr. 2 p13 |
TIA1 is a 3'UTR mRNA binding protein and can bind the 5'TOPsequence of 5'TOP mRNAs. It is associated with programmed cell death (apoptosis) and regulates alternative splicing of the gene encoding the Fas receptor, an apoptosis-promoting protein.[1]
Notes
- ↑ Izquierdo JM, Majós N, Bonnal S et al. (August 2005). "Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definition". Mol. Cell 19 (4): 475–84. doi:10.1016/j.molcel.2005.06.015. PMID 16109372.
See also
- Stress granule
- T-cell large granular lymphocyte leukemia
External links
- TIA1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)