THSD1
| Thrombospondin, type I, domain containing 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | THSD1 ; TMTSP; UNQ3010 | ||||||||||
| External IDs | MGI: 1929096 HomoloGene: 10264 GeneCards: THSD1 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 55901 | 56229 | |||||||||
| Ensembl | ENSG00000136114 | ENSMUSG00000031480 | |||||||||
| UniProt | Q9NS62 | Q9JM61 | |||||||||
| RefSeq (mRNA) | NM_018676 | NM_001205253 | |||||||||
| RefSeq (protein) | NP_061146 | NP_001192182 | |||||||||
| Location (UCSC) | Chr 13: 52.95 – 52.98 Mb | Chr 8: 22.23 – 22.26 Mb | |||||||||
| PubMed search | |||||||||||
Thrombospondin type-1 domain-containing protein 1 is a protein that in humans is encoded by the THSD1 gene.[1]
The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in thrombospondin, a number of proteins involved in the complement pathway, as well as extracellular matrix proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[1]
References
Further reading
- Bork P (1993). "The modular architecture of a new family of growth regulators related to connective tissue growth factor". FEBS Lett. 327 (2): 125–30. doi:10.1016/0014-5793(93)80155-N. PMID 7687569.
- Gruber HE, Ingram JA, Hanley EN (2007). "Immunolocalization of thrombospondin in the human and sand rat intervertebral disc". Spine 31 (22): 2556–61. doi:10.1097/01.brs.0000241117.31510.e3. PMID 17047544.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Orr AW, Pallero MA, Xiong WC, Murphy-Ullrich JE (2005). "Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly". J. Biol. Chem. 279 (47): 48983–92. doi:10.1074/jbc.M404881200. PMID 15371459.
- Dunham A; Matthews LH; Burton J et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Clark HF; Gurney AL; Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.