TH1L
| Negative elongation factor complex member C/D | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | NELFCD ; NELF-C; NELF-D; TH1; TH1L | ||||||||||||
| External IDs | OMIM: 605297 MGI: 1926424 HomoloGene: 9496 GeneCards: NELFCD Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 51497 | 57314 | |||||||||||
| Ensembl | ENSG00000101158 | ENSMUSG00000016253 | |||||||||||
| UniProt | Q8IXH7 | Q922L6 | |||||||||||
| RefSeq (mRNA) | NM_016397 | NM_020580 | |||||||||||
| RefSeq (protein) | NP_945327 | NP_065605 | |||||||||||
| Location (UCSC) | Chr 20: 57.56 – 57.57 Mb | Chr 2: 174.42 – 174.43 Mb | |||||||||||
| PubMed search | |||||||||||||
Negative elongation factor C/D is a protein that in humans is encoded by the TH1L gene.[1][2][3]
The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini.[3]
Interactions
TH1L has been shown to interact with RDBP,[4][5] ARAF[6][7] and Cofactor of BRCA1.[4][5]
References
- ↑ Bonthron DT, Hayward BE, Moran V, Strain L (Oct 2000). "Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13". Hum Genet 107 (2): 165–75. doi:10.1007/s004390000344. PMID 11030415.
- ↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- ↑ 3.0 3.1 "Entrez Gene: TH1L TH1-like (Drosophila)".
- ↑ 4.0 4.1 Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- ↑ 5.0 5.1 Narita, Takashi; Yamaguchi Yuki, Yano Keiichi, Sugimoto Seiji, Chanarat Sittinan, Wada Tadashi, Kim Dong-ki, Hasegawa Jun, Omori Masashi, Inukai Naoto, Endoh Masaki, Yamada Tomoko, Handa Hiroshi (Mar 2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex". Mol. Cell. Biol. (United States) 23 (6): 1863–73. doi:10.1128/MCB.23.6.1863-1873.2003. ISSN 0270-7306. PMC 149481. PMID 12612062.
- ↑ Yuryev, Anton; Wennogle Lawrence P (Feb 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics (United States) 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389.
- ↑ Yin, Xiang L; Chen She; Gu Jian X (Feb 2002). "Identification of TH1 as an interaction partner of A-Raf kinase". Mol. Cell. Biochem. (Netherlands) 231 (1-2): 69–74. doi:10.1023/A:1014437024129. ISSN 0300-8177. PMID 11952167.
Further reading
- Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention.". Med Res Rev 26 (5): 595–625. doi:10.1002/med.20081. PMID 16838299.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Yamaguchi Y, Takagi T, Wada T et al. (1999). "NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.". Cell 97 (1): 41–51. doi:10.1016/S0092-8674(00)80713-8. PMID 10199401.
- Ping YH, Rana TM (2001). "DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation.". J. Biol. Chem. 276 (16): 12951–8. doi:10.1074/jbc.M006130200. PMID 11112772.
- Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Yin XL, Chen S, Gu JX (2002). "Identification of TH1 as an interaction partner of A-Raf kinase.". Mol. Cell. Biochem. 231 (1-2): 69–74. doi:10.1023/A:1014437024129. PMID 11952167.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Narita T, Yamaguchi Y, Yano K et al. (2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.". Mol. Cell. Biol. 23 (6): 1863–73. doi:10.1128/MCB.23.6.1863-1873.2003. PMC 149481. PMID 12612062.
- Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.". Genomics 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
- Liu W, Shen X, Yang Y et al. (2004). "Trihydrophobin 1 is a new negative regulator of A-Raf kinase.". J. Biol. Chem. 279 (11): 10167–75. doi:10.1074/jbc.M307994200. PMID 14684750.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Colland F, Jacq X, Trouplin V et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Stelzl U, Worm U, Lalowski M et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Yang Y, Liu W, Zou W et al. (2007). "Ubiquitin-dependent proteolysis of trihydrophobin 1 (TH1) by the human papilloma virus E6-associated protein (E6-AP).". J. Cell. Biochem. 101 (1): 167–80. doi:10.1002/jcb.21164. PMID 17131388.
- Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.