TGS1

Trimethylguanosine synthase 1

Rendering based on PDB 3GDH.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsTGS1 ; NCOA6IP; PIMT; PIPMT
External IDsOMIM: 606461 MGI: 2151797 HomoloGene: 32608 GeneCards: TGS1 Gene
EC number2.1.1.-
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez96764116940
EnsemblENSG00000137574ENSMUSG00000028233
UniProtQ96RS0Q923W1
RefSeq (mRNA)NM_024831NM_054089
RefSeq (protein)NP_079107NP_473430
Location (UCSC)Chr 8:
56.69 – 56.74 Mb
Chr 4:
3.57 – 3.62 Mb
PubMed search

Trimethylguanosine synthase is an enzyme that in humans is encoded by the TGS1 gene.[1][2][3]

Interactions

TGS1 has been shown to interact with:

References

  1. 1.0 1.1 Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK (Aug 2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc Natl Acad Sci U S A 98 (18): 10380–5. doi:10.1073/pnas.181347498. PMC 56969. PMID 11517327.
  2. Mouaikel J, Verheggen C, Bertrand E, Tazi J, Bordonné R (May 2002). "Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus". Mol Cell 9 (4): 891–901. doi:10.1016/S1097-2765(02)00484-7. PMID 11983179. Vancouver style error (help)
  3. "Entrez Gene: TGS1 trimethylguanosine synthase homolog (S. cerevisiae)".
  4. 4.0 4.1 4.2 4.3 Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS et al. (May 2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi:10.1074/jbc.M201739200. PMID 11912212.
  5. Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I (Sep 2003). "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus". Biochem. Biophys. Res. Commun. 309 (1): 44–51. doi:10.1016/s0006-291x(03)01514-6. PMID 12943661. Vancouver style error (help)

Further reading