TFCP2

Transcription factor CP2
Identifiers
SymbolsTFCP2 ; LBP1C; LSF; LSF1D; SEF; TFCP2C
External IDsOMIM: 189889 MGI: 98509 HomoloGene: 4134 GeneCards: TFCP2 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez702421422
EnsemblENSG00000135457ENSMUSG00000009733
UniProtQ12800Q9ERA0
RefSeq (mRNA)NM_001173452NM_001289603
RefSeq (protein)NP_001166923NP_001276532
Location (UCSC)Chr 12:
51.49 – 51.57 Mb		Chr 15:
100.5 – 100.55 Mb
PubMed search

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.[1][2]

TFCP2 is also called Late SV40 factor (LSF) and it is induced by well known oncogene AEG-1.[3] Late SV40 factor (LSF) also acts as an oncogene in hepatocellular carcinoma.[4] Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).[5]

Along with its main oncogene function in hepatocellular carcinoma (HCC) it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease.[4][6] The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding to HCC DNA which results in HCC cell death.[4][6][7]

Interactions

TFCP2 has been shown to interact with APBB1[8] and RNF2.[9]

References

  1. ↑ Swendeman SL, Spielholz C, Jenkins NA, Gilbert DJ, Copeland NG, Sheffery M (May 1994). "Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2". J Biol Chem 269 (15): 11663–71. PMID 8157699.
  2. ↑ "Entrez Gene: TFCP2 transcription factor CP2".
  3. ↑ Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher PB, Sarkar D (August 2009). "Identification of genes conferring resistance to 5-fluorouracil". Proc. Natl. Acad. Sci. U.S.A. 106 (31): 12938–43. doi:10.1073/pnas.0901451106. PMC 2722317. PMID 19622726.
  4. ↑ 4.0 4.1 4.2 Yoo BK, Emdad L, Gredler R, Fuller C, Dumur CI, Jones KH, Jackson-Cook C, Su ZZ, Chen D, Saxena UH, Hansen U, Fisher PB, Sarkar D (May 2010). "Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma". Proc. Natl. Acad. Sci. U.S.A. 107 (18): 8357–62. doi:10.1073/pnas.1000374107. PMC 2889542. PMID 20404171.
  5. ↑ Santhekadur PK, Gredler R, Chen D, Siddiq A, Shen XN, Das SK, Emdad L, Fisher PB, Sarkar D (January 2012). "Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9)". J. Biol. Chem. 287 (5): 3425–32. doi:10.1074/jbc.M111.298976. PMC 3270996. PMID 22167195.
  6. ↑ 6.0 6.1 Santhekadur PK, Rajasekaran D, Siddiq A, Gredler R, Chen D, Schaus SC, Hansen U, Fisher PB, Sarkar D (2012). "The transcription factor LSF: a novel oncogene for hepatocellular carcinoma". Am J Cancer Res 2 (3): 269–285.
  7. ↑ Grant TJ, Bishop JA, Christadore LM, Barot G, Chin HG, Woodson S, Kavouris J, Siddiq A, Gredler R, Shen XN, Sherman J, Meehan T, Fitzgerald K, Pradhan S, Briggs LA, Andrews WH, Sarkar D, Schaus SE, Hansen U (March 2012). "Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma". Proc. Natl. Acad. Sci. U.S.A. 109 (12): 4503–8. doi:10.1073/pnas.1121601109. PMC 3311344. PMID 22396589. Lay summary – Science Codex.
  8. ↑ Zambrano N, Minopoli G, de Candia P, Russo T (August 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". J. Biol. Chem. 273 (32): 20128–33. doi:10.1074/jbc.273.32.20128. PMID 9685356.
  9. ↑ Tuckfield A, Clouston DR, Wilanowski TM, Zhao LL, Cunningham JM, Jane SM (March 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Mol. Cell. Biol. 22 (6): 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. PMC 135618. PMID 11865070.

Further reading