TFB2M

Transcription factor B2, mitochondrial

Identifiers

TFB2M ; Hkp1; mtTFB2

External IDs

OMIM: 607055 MGI: 107937 HomoloGene: 7362 GeneCards: TFB2M Gene

Gene ontology
Molecular function	• rRNA (adenine-N6,N6-)-dimethyltransferase activity • transcription cofactor activity • poly(A) RNA binding
Cellular component	• mitochondrial matrix • mitochondrial nucleoid
Biological process	• transcription from mitochondrial promoter • transcription initiation from mitochondrial promoter • gene expression • rRNA methylation • positive regulation of transcription, DNA-templated
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000162851

ENSMUSG00000026492

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
246.7 – 246.73 Mb

Chr 1:
179.53 – 179.55 Mb

PubMed search

Dimethyladenosine transferase 2, mitochondrial is an enzyme that in humans is encoded by the TFB2M gene.^[1]

References

↑ "Entrez Gene: TFB2M transcription factor B2, mitochondrial".

Further reading

Falkenberg M, Gaspari M, Rantanen A et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.". Nat. Genet. 31 (3): 289–94. doi:10.1038/ng909. PMID 12068295.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rantanen A, Gaspari M, Falkenberg M et al. (2003). "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2.". Mamm. Genome 14 (1): 1–6. doi:10.1007/s00335-002-2218-z. PMID 12532263.
McCulloch V, Shadel GS (2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity.". Mol. Cell. Biol. 23 (16): 5816–24. doi:10.1128/MCB.23.16.5816-5824.2003. PMC 166325. PMID 12897151.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gaspari M, Falkenberg M, Larsson NG, Gustafsson CM (2005). "The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells.". EMBO J. 23 (23): 4606–14. doi:10.1038/sj.emboj.7600465. PMC 533051. PMID 15526033.
Gleyzer N, Vercauteren K, Scarpulla RC (2005). "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators.". Mol. Cell. Biol. 25 (4): 1354–66. doi:10.1128/MCB.25.4.1354-1366.2005. PMC 548005. PMID 15684387.
Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Cotney J, Shadel GS (2007). "Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2.". J. Mol. Evol. 63 (5): 707–17. doi:10.1007/s00239-006-0075-1. PMID 17031457.
Cotney J, Wang Z, Shadel GS (2007). "Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression.". Nucleic Acids Res. 35 (12): 4042–54. doi:10.1093/nar/gkm424. PMC 1919481. PMID 17557812.