TENC1
Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.[1]
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[1]
Interactions
TENC1 has been shown to interact with AXL receptor tyrosine kinase.[2]
References
Further reading
- Kikuno R, Nagase T, Ishikawa K et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
- Chen H, Duncan IC, Bozorgchami H, Lo SH (2002). "Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration.". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 733–8. doi:10.1073/pnas.022518699. PMC 117374. PMID 11792844.
- Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.". Biochem. Biophys. Res. Commun. 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. PMID 12470648.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Calderwood DA, Fujioka Y, de Pereda JM et al. (2003). "Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2272–7. doi:10.1073/pnas.262791999. PMC 151330. PMID 12606711.
- Hu Y, Fang X, Dunham SM et al. (2004). "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling.". J. Biol. Chem. 279 (28): 29325–35. doi:10.1074/jbc.M311144200. PMID 15117958.
- Hafizi S, Ibraimi F, Dahlbäck B (2006). "C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration.". FASEB J. 19 (8): 971–3. doi:10.1096/fj.04-2532fje. PMID 15817639.
- Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Yam JW, Ko FC, Chan CY et al. (2006). "Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma.". Hepatology 44 (4): 881–90. doi:10.1002/hep.21339. PMID 17006924.
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| | 2dkq: Solution structure of the PTB domain of KIAA1075 protein from human |
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