TBC1D1

TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3QYE

Identifiers

TBC1D1 ; TBC; TBC1

External IDs

OMIM: 609850 MGI: 1889508 HomoloGene: 56856 GeneCards: TBC1D1 Gene

Gene ontology
Molecular function	• Rab GTPase activator activity
Cellular component	• nucleus • cytosol
Biological process	• positive regulation of Rab GTPase activity • regulation of protein localization • membrane organization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000065882

ENSMUSG00000029174

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
37.89 – 38.14 Mb

Chr 5:
64.16 – 64.35 Mb

PubMed search

TBC1 domain family member 1 is a protein that in humans is encoded by the TBC1D1 gene.^[1]^[2]

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000).[supplied by OMIM]^[2]

References

↑ White RA, Pasztor LM, Richardson PM, Zon LI (Sep 2000). "The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4". Cytogenet Cell Genet 89 (3-4): 272–5. doi:10.1159/000015632. PMID 10965142.
↑ 2.0 2.1 "Entrez Gene: TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1".

Further reading

Nakajima D, Okazaki N, Yamakawa H et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Roach WG, Chavez JA, Mîinea CP, Lienhard GE (2007). "Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1.". Biochem. J. 403 (2): 353–8. doi:10.1042/BJ20061798. PMC 1874243. PMID 17274760.
Stone S, Abkevich V, Russell DL et al. (2006). "TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition.". Hum. Mol. Genet. 15 (18): 2709–20. doi:10.1093/hmg/ddl204. PMID 16893906.
Otsuki T, Ota T, Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Rush J, Moritz A, Lee KA et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Jin J, Smith FD, Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Colland F, Jacq X, Trouplin V et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kikuno R, Nagase T, Ishikawa K et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.