TAPI-1
 | |
| Names | |
|---|---|
| IUPAC name
N1-((S)-1-((S)-1-(2-aminoethylamino)-1-oxopropan-2-ylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccin amide | |
| Identifiers | |
| 171235-71-5 | |
| Properties | |
| Molecular formula |
C26H37N5O5 |
| Molar mass | 499.60 g·mol−1 |
| Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
| Infobox references | |
TAPI-1 ( TNF-alpha protease inhibitor I) is a structural analog of TAPI-0 with similar but more stable validness in vitro for the matrix metalloproteinases (MMPs) and TNF- alpha converting enzyme[1] which blocks shedding of several cell surface proteins such as IL-6 and p60 TNF receptor.[2]
References
- ↑ Müllberg J rt al; Durie; Otten-Evans; Alderson; Rose-John; Cosman; Black; Mohler (Dec 1, 1995). "A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor". J Immunol 155 (11): 5198–5205. PMID 7594530.
- ↑ "TAPI-1 biological activity". selleckchemicals.