T-cell lymphoma invasion and metastasis-inducing protein 1

T-cell lymphoma invasion and metastasis 1

PDB rendering based on 1foe.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2D8I, 3KZD, 3KZE, 4GVC, 4GVD, 4K2O, 4K2P

Identifiers

Symbols

TIAM1 ; FLJ36302

External IDs

OMIM: 600687 MGI: 103306 HomoloGene: 2443 GeneCards: TIAM1 Gene

Gene ontology
Molecular function	• receptor signaling protein activity • Rho guanyl-nucleotide exchange factor activity • phospholipid binding • Rac guanyl-nucleotide exchange factor activity • ephrin receptor binding
Cellular component	• cytosol • cell-cell junction • extrinsic component of cytoplasmic side of plasma membrane • cell-cell contact zone
Biological process	• cell-matrix adhesion • small GTPase mediated signal transduction • cell migration • Rac protein signal transduction • positive regulation of Rho GTPase activity • positive regulation of Rac GTPase activity • positive regulation of apoptotic process • neurotrophin TRK receptor signaling pathway • ephrin receptor signaling pathway • positive regulation of axonogenesis • regulation of small GTPase mediated signal transduction • apoptotic signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 21:
31.12 – 31.56 Mb

Chr 16:
89.79 – 89.98 Mb

PubMed search

T-cell lymphoma invasion and metastasis-inducing protein 1 is a protein that in humans is encoded by the TIAM1 gene.^[1]^[2]^[3]

Structure

TIAM1 is tightly associate with BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain.

Function

TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA.

Clinical significance

TIAM1 is found in virtually all tumor cell lines examined including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

Interactions

T-cell lymphoma invasion and metastasis-inducing protein 1 has been shown to interact with ANK1,^[4] Myc,^[5] RAC1^[6]^[7] and PPP1R9B.^[8]

Tiam1 interacts also with para-cingulin, that plays a role in recruiting Tiam1 to junctions and thus activate Rac1 at epithelial junctions.^[9]

References

↑ "Entrez Gene: TIAM1 T-cell lymphoma invasion and metastasis 1".
↑ Chen H, Antonarakis SE (November 1995). "Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1". Genomics 30 (1): 123–7. doi:10.1006/geno.1995.0025. PMID 8595894.
↑ Uhlenbrock K, Eberth A, Herbrand U, Daryab N, Stege P, Meier F, Friedl P, Collard JG, Ahmadian MR (September 2004). "The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism". J. Cell. Sci. 117 (Pt 20): 4863–71. doi:10.1242/jcs.01367. PMID 15340013.
↑ Bourguignon, L Y; Zhu H; Shao L; Chen Y W (July 2000). "Ankyrin–Tiam1 Interaction Promotes Rac1 Signaling and Metastatic Breast Tumor Cell Invasion and Migration". J. Cell Biol. (UNITED STATES) 150 (1): 177–91. doi:10.1083/jcb.150.1.177. ISSN 0021-9525. PMC 2185563. PMID 10893266.
↑ Otsuki, Yoshiro; Tanaka Masamitsu; Kamo Takaharu; Kitanaka Chifumi; Kuchino Yoshiyuki; Sugimura Haruhiko (February 2003). "Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts". J. Biol. Chem. (United States) 278 (7): 5132–40. doi:10.1074/jbc.M206733200. ISSN 0021-9258. PMID 12446731.
↑ Worthylake, D K; Rossman K L; Sondek J (Dec 2000). "Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1". Nature (England) 408 (6813): 682–8. doi:10.1038/35047014. ISSN 0028-0836. PMID 11130063.
↑ Gao, Y; Xing J; Streuli M; Leto T L; Zheng Y (Dec 2001). "Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors". J. Biol. Chem. (United States) 276 (50): 47530–41. doi:10.1074/jbc.M108865200. ISSN 0021-9258. PMID 11595749.
↑ Buchsbaum, Rachel J; Connolly Beth A; Feig Larry A (May 2003). "Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin". J. Biol. Chem. (United States) 278 (21): 18833–41. doi:10.1074/jbc.M207876200. ISSN 0021-9258. PMID 12531897.
↑ Guillemot L, Paschoud S, Jond L, Foglia A, Citi S (October 2008). "Paracingulin Regulates the Activity of Rac1 and RhoA GTPases by Recruiting Tiam1 and GEF-H1 to Epithelial Junctions". Mol. Biol. Cell 19 (10): 4442–53. doi:10.1091/mbc.E08-06-0558. PMC 2555940. PMID 18653465.

Habets GG; van der Kammen RA; Stam JC et al. (1995). "Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin". Oncogene 10 (7): 1371–6. PMID 7731688.
Habets GG; van der Kammen RA; Jenkins NA et al. (1995). "The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16". Cytogenet. Cell Genet. 70 (1–2): 48–51. doi:10.1159/000133989. PMID 7736788.
Michiels F; Habets GG; Stam JC et al. (1995). "A role for Rac in Tiam1-induced membrane ruffling and invasion". Nature 375 (6529): 338–40. doi:10.1038/375338a0. PMID 7753201.
Andersson B; Wentland MA; Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Michiels F; Stam JC; Hordijk PL et al. (1997). "Regulated Membrane Localization of Tiam1, Mediated by the NH2-terminal Pleckstrin Homology Domain, Is Required for Rac-dependent Membrane Ruffling and C-Jun NH2-terminal Kinase Activation". J. Cell Biol. 137 (2): 387–98. doi:10.1083/jcb.137.2.387. PMC 2139766. PMID 9128250.
Fleming IN; Elliott CM; Buchanan FG et al. (1999). "Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation". J. Biol. Chem. 274 (18): 12753–8. doi:10.1074/jbc.274.18.12753. PMID 10212259.
Bourguignon LY, Zhu H, Shao L, Chen YW (2000). "CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration". J. Biol. Chem. 275 (3): 1829–38. doi:10.1074/jbc.275.3.1829. PMID 10636882.
Hattori M; Fujiyama A; Taylor TD et al. (2000). "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Crompton AM; Foley LH; Wood A et al. (2000). "Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands". J. Biol. Chem. 275 (33): 25751–9. doi:10.1074/jbc.M002050200. PMID 10835422.
Bourguignon LY, Zhu H, Shao L, Chen YW (2000). "Ankyrin–Tiam1 Interaction Promotes Rac1 Signaling and Metastatic Breast Tumor Cell Invasion and Migration". J. Cell Biol. 150 (1): 177–91. doi:10.1083/jcb.150.1.177. PMC 2185563. PMID 10893266.
Worthylake DK, Rossman KL, Sondek J (2001). "Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1". Nature 408 (6813): 682–8. doi:10.1038/35047014. PMID 11130063.
Otsuki Y; Tanaka M; Yoshii S et al. (2001). "Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4385–90. doi:10.1073/pnas.071411598. PMC 31844. PMID 11274357.
Gao Y; Xing J; Streuli M et al. (2002). "Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors". J. Biol. Chem. 276 (50): 47530–41. doi:10.1074/jbc.M108865200. PMID 11595749.
Buchsbaum RJ, Connolly BA, Feig LA (2002). "Interaction of Rac Exchange Factors Tiam1 and Ras-GRF1 with a Scaffold for the p38 Mitogen-Activated Protein Kinase Cascade". Mol. Cell. Biol. 22 (12): 4073–85. doi:10.1128/MCB.22.12.4073-4085.2002. PMC 133864. PMID 12024021.
Lambert JM; Lambert QT; Reuther GW et al. (2002). "Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism". Nat. Cell Biol. 4 (8): 621–5. doi:10.1038/ncb833. PMID 12134164.
Wennerberg K; Ellerbroek SM; Liu RY et al. (2003). "RhoG signals in parallel with Rac1 and Cdc42". J. Biol. Chem. 277 (49): 47810–7. doi:10.1074/jbc.M203816200. PMID 12376551.
Otsuki Y; Tanaka M; Kamo T et al. (2003). "Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts". J. Biol. Chem. 278 (7): 5132–40. doi:10.1074/jbc.M206733200. PMID 12446731.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Buchsbaum RJ, Connolly BA, Feig LA (2003). "Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin". J. Biol. Chem. 278 (21): 18833–41. doi:10.1074/jbc.M207876200. PMID 12531897.

PDB gallery

1foe: CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1

2d8i: Solution structure of the PDZ domain of T-cell lymphoma invasion and metastasis 1 varian

External links

UMich Orientation of Proteins in Membranes protein/pdbid-1foe - Calculated spatial position of TIAM1-RAC2 complex in membrane